Hormonal Modulation of Progesterone Receptors

  • Judith Saffran
  • Bonnie K. Loeser
Part of the Biochemical Endocrinology book series (BIOEND)


According to current theories of hormone action, all the steroid hormones, including vitamin D, exert their effects in a similar way (Buller and O’Malley, 1976; Chan and O’Malley, 1976; DeLuca, 1979; Gorski and Gannon, 1976; Yamamoto and Alberts, 1976). There is general, but not universal, agreement that the hormone diffuses passively through the cell membrane (Baulieu, 1978). After entering the target cell, the hormone binds to a cytoplasmic receptor protein that is present only in target cells and that is fairly specific for the hormone. The binding is of high affinity, with equilibrium dissociation constants in the neighborhood of 10-9 M. Because there is a limited number of receptor molecules per cell, the binding of the hormone is saturable. The complex of hormone and receptor then undergoes a process of “activation” or “transformation” that enables it to enter the nucleus and bind to chromatin. This binding initiates the biochemical events that are characteristic of the hormone. There is increased transcription, resulting eventually in an increase in protein synthesis.


Progesterone Receptor Estrous Cycle Hormonal Modulation Cytoplasmic Receptor Progesterone Action 
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  1. Anderson, J.N., Peck, E.J., and Clark, J.H., 1974, Nuclear receptor estradiol complex: A requirement for uterotrophic responses, Endocrinology 95: 174–178.CrossRefGoogle Scholar
  2. Armstrong, D.T., and King, E.R., 1971, Uterine progesterone metabolism and progesta- tional response: Effects of estrogens and prolactin, Endocrinology 89: 191–197.CrossRefGoogle Scholar
  3. Bardin, C.W., Bullock, L.P., Jänne, O., and Jacob, S.T., 1975, Genetic regulation of the androgen receptor—a study of testicular feminization in the mouse, J. Steroid Biochem. 6: 515–520.CrossRefGoogle Scholar
  4. Basha, S.M.M., Bazer, F.W., and Roberts, R.M., 1979, The secretion of uterines purple phosphatase by cultured explants of porcine endometrium dependency upon the state of pregnancy of the donor animal, Biol. Reprod. 20: 431–441.CrossRefGoogle Scholar
  5. Batra, S., Sjoberg, N.O., and Norbert, G.T., 1978, Estrogen and progesterone interactions in the rabbit uterus in vivo after steroid administration, Endocrinology 102: 268–272.CrossRefGoogle Scholar
  6. Baudendistel, L.J., Ruh, M.F., Nadel, E.M., and Ruh, T.S 1978, Cytoplasmic oestrogen receptor replenishment: Oestrogens vs. anti-oestrogens, Acta Endocrinol. 89: 599–611.Google Scholar
  7. Baulieu, E.-E., 1978, Cell membrane, a target for steroid hormones, Mol. Cell Endocrinol. 12: 247–254.CrossRefGoogle Scholar
  8. Bayard, F., Damilano, S., Robel, P., and Baulieu, E.-E., 1978, Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium, J. Clin. Endocrinol. Metab. 46: 635–648.CrossRefGoogle Scholar
  9. Beir, H.M., 1974, A hormone-sensitive endometrial protein in blastocyst development, J. Reprod. Fertil. 37: 221–237.Google Scholar
  10. Booth, B.A., and Colas, A.E., 1977, Properties of two progesterone-binding proteins of the rat uterus, J. Steroid Biochem. 8: 1171–1177.CrossRefGoogle Scholar
  11. Brenner, R.M., and West, N.B., 1975, Hormonal regulation of the reproductive tract in female mammals, Anna. Rev. Physiol. 37: 273–302.CrossRefGoogle Scholar
  12. Buller, R.E., and O’Malley, B.W., 1976, The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus, Biochem. Pharmacol.251612.Google Scholar
  13. Capony, F., and Rochefort, H., 1978, High-affinity binding of the antiestrogen [3HJtamoxifen to the 8S estradiol receptor, Mol. Cell Endocrnol. 11: 181–198.CrossRefGoogle Scholar
  14. Chan, L., and O’Malley, B.W., 1976, Mechanism of action of the sex steroid hormones, N.Engl. J. Med. 294:1322–1328, 1372–1381, 1430–1437.CrossRefGoogle Scholar
  15. Chen, T.J., and Leavitt, W.W., 1979, Nuclear progesterone receptor in hamster uterus: Measurement by PHI-progesterone exchange during the estrous cycle, Endocrinology 104: 1588–1597.CrossRefGoogle Scholar
  16. Cheng, Y.-J., and Karavolas, H.J., 1973, Conversion of progesterone to 5a-pregnane-3,20dione and 3a-hydroxy-5a-pregnane-20-one by rat medial basal hypothalami and the effects of estradiol and stage of the estrous cycle on the conversion, Endocrinology 93: 1157–1162.CrossRefGoogle Scholar
  17. Cidlowski, J.A., and Muldoon, T.G., 1974, Estrogenic regulation of cytoplasmic receptor populations in estrogen-responsive tissues of the rat, Endocrinology 95: 1621–1629.CrossRefGoogle Scholar
  18. Clark, J.H., Anderson, J.N., and Peck, E.J., 1973, Estrogen receptor—antiestrogen complex: Atypical binding by uterine nuclei and effects on uterine growth, Steroids 2: 707–718.CrossRefGoogle Scholar
  19. Coulson, P.B., and Pavlik, E.J., 1977, Effects of estrogen and progesterone on cytoplasmic estrogen receptor and rates of protein synthesis, J. Steroid Biochem. 8: 205–212.CrossRefGoogle Scholar
  20. Csapo, A.J., and Wiest, W.G., 1969, An examination of the quantitative relationship between progesterone and the maintenance of pregnancy, Endocrinology 85: 735–746.CrossRefGoogle Scholar
  21. DeLuca, H., 1979, Recent advances in our understanding of the vitamin D endocrine system, J. Steroid Biochem. 11: 35–52.CrossRefGoogle Scholar
  22. Edwards, D.P., Chamness, G.C., and McGuire, W.L., 1979, Estrogen and progesterone receptor proteins in breast cancer, Biochim. Biophys. Acta 560: 457–486.Google Scholar
  23. Elsner, C.W., Illingworth, D.V., dela Cruz, K., Flickinger, G.L., and Mikhail, G., 1977, Cytosol and nuclear estrogen receptor in the genital tract of the rhesus monkey, J.Steroid Biochem. 8: 151–155.CrossRefGoogle Scholar
  24. Evans, Y.W., Sholiton, L.J., and Leavitt, W.W., 1978, Progesterone receptor in the rat anterior pituitary: Effect of estrogen priming and adrenalectomy, Steroids 31: 69–81.CrossRefGoogle Scholar
  25. Faber, L.E., Sandmann, M.L., and Stavely, H.E., 1972, Progesterone-binding proteins of the rat and rabbit uterus, J. Biol. Chem. 247: 5648–5649.Google Scholar
  26. Faber, L.E., Sandmann, M.L., and Stavely, H.E., 1978, Effect of buffers and electrolytes on the stability of uterine progesterone receptors, Biochem. Med. 19: 78–89.CrossRefGoogle Scholar
  27. Feil, P.D., Glasser, S.R., Toft, D.O., and O’Malley, B.W., 1972, Progesterone binding in the mouse and rat uterus, Endocrinology 91: 738–746.CrossRefGoogle Scholar
  28. Feil, P.D., Marni, W.J., Mortel, R., and Bardin, C.W., 1979, Nuclear progesterone receptors in normal and malignant human endometrium, J. Clin. Endocrinol. Metab. 48: 327–334.CrossRefGoogle Scholar
  29. Flier, J.S., Kahn, C.R., Roth, J., and Bar, R.S., 1975, Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance,Science 190: 63–65.Google Scholar
  30. Freifeld, M.L., Feil, P.D., and Bardin, C.W., 1974, The in vivo regulation of the progesterone receptor in guinea pig uterus: Dependence on estrogen and progesterone,Steroids 23: 93–103.Google Scholar
  31. Giannina, T., and Meli, A., 1990 Estrogen—progesterone interaction: Factors influencing progesterone-induced endometrial changes of the uterus of the immature rabbit, Proc. Soc., Exp. Biol. Med. 151: 591–593.Google Scholar
  32. Giannopoulos, G., and Tulchinsky, D., 1979, Cytoplasmic and nuclear progestin receptors in human myometrium during the menstrual cycle and in pregnancy at term, J. Clin. Endocrinol. Metab. 49: 100–106.CrossRefGoogle Scholar
  33. Gorski, J., and Gannon, F., 1976, Current models of steroid hormone action: A critique, Annu. Rev. Physiol. 38: 425–450.Google Scholar
  34. Groyer, A., Picard-Groyer, M.T., and Robel, P., 1979, Glucocorticoid receptor in human embryo fibroblasts. 1. Kinetic and Physicochemical properties, Mol. Cell Endocrinol. 13: 255–267.CrossRefGoogle Scholar
  35. Horwitz, K.B., and McGuire, W.L., 1978a, Estrogen control of progesterone receptor in human breast cancer correlation with nuclear processing of estrogen receptor, J. Biol. Chem. 253: 2223–2228.Google Scholar
  36. Horwitz, K.B., and McGuire, W.L., 19786, Actinomycin D prevents nuclear processing of estrogen receptor, J. Biol. Chem. 253: 6319–6322.Google Scholar
  37. Horwitz, K.B., Koseki, Y., and McGuire, W.L., 1978, Estrogen control of progestero receptor in human breast cancer: Role of estradiol and antiestrogen, Endocrinology 103: 1742–1751.CrossRefGoogle Scholar
  38. Hsueh, A.J.W., Peck, E.J., and Clark,J.H. 1975, Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growth, Nature (London) 254:337–339.CrossRefGoogle Scholar
  39. lllingworth, D.V., Elsner, C., de Groot dela Cruz, K., Flickinger, G.L., and Mikhail, G., 1977, A specific progesterone receptor of myometrial cytosol from the rhesus monkey, J. Steroid Biochem. 8: 157–160.Google Scholar
  40. lsomaa, V., Isotala, H., Orava, M., and Jänne, 0., 1979, Regulation of cytosol and nuclear progesterone receptors in rabbit uterus by estrogen, antiestrogen and progesterone administration, Biochem. Biophys. Acta 585: 24–33.CrossRefGoogle Scholar
  41. Jänne, O., Kontula, K., Luukkainen, T., and Vihko, R., 1975, Oestrogen-induced progesterone receptor in human uterus, J. Steroid Biochem. 6: 501–509.CrossRefGoogle Scholar
  42. Juliano, J.V., and Stance(, G.M., 1976, Estrogen receptors in the rat uterus retention of hormone—receptor complexes, Biochemistry 15: 916–920.CrossRefGoogle Scholar
  43. Kahn, C.R., Flier, J.S., Bar, R.S., Archer, J.A., Gorden, P., Martin, M.M., and Roth, J., 1976, The syndromes of insulin resistance and acanthosis nigricans: Insulin receptor disorders in man, N. Engl. J. Med. 294: 739–745.CrossRefGoogle Scholar
  44. Karavolas, H.J., Hodges, D.R., and O’Brien, D.J., 1976, Uptake of [’H]-progesterone and l ‘H1–5a-dihydroprogesterone by rat tissues in vivo and analysis of accumulated radioactivity: Accumulation of 5a-dihydroprogesterone by pituitary and hypothalamic tissues, Endocrinology 98.:164–175CrossRefGoogle Scholar
  45. Karavolas, H.J., Hodges, D.R., and O’Brien, D.J., 1979, The in viro uptake and metabolism of [’H]progesterone and {3H]-5a-dihydroprogesterone by rat CNS and anterior pituitary: Tissue concentration of progesterone itself or metabolites?, J. Steroid Biochem. 11: 863–872.CrossRefGoogle Scholar
  46. Katzenellenbogen, B.S., 1975, Synthesis and inducibility of the uterine estrogen-induced protein IP during the rat estrous cycle: Clues to uterine estrogen sensitivity, Endocrinology 96: 289–297.CrossRefGoogle Scholar
  47. Katzenellenbogen, B.S., Katzenellenbogen, J.A., Ferguson, E.R., and Krauthammer, N., 1978, Anti-estrogen interaction with uterine estrogen receptors studies with radiolabeled antiestrogen (CI-628), J. Biol. Chem. 253: 697–707.Google Scholar
  48. Katzenellenbogen, B.S., Tsai, T., Tatee, T., and Katzenellenbogen, J.A., 1979, Estrogen and antiestrogenic action: Studies in reproductive target tissues and tumors, in: Steroid Hormone Receptor Systems. (W.W.Leavitt and J.H. Clark, eds.), pp. 111–132, Plenum Press, New York.Google Scholar
  49. Kaufman, M., Straisfeld, C., and Pinsky, L., 1976, Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens: Deficient 5a-dihydrotestosterone binding in cultured skin fibroblasts, J. Clin. Invest. 58: 345–350.CrossRefGoogle Scholar
  50. Kielhorn, J., and Hughes, A., 1977, Variations in uterine cytosolic oestrogen receptor levels during the rat oestrous cycle, Acta Endocr-850.Google Scholar
  51. Koligian, K.B., and Stormshak, F., 1977a, Nuclear and cytoplasmic estrogen receptors in ovine endometrium during the estrous cycle, Endocrinology 101: 524–533.CrossRefGoogle Scholar
  52. Koligian, K.B., and Stormshak, F., 1977b, Progesterone inhibition of estrogen receptor replenishment in ovine endometrium, Biol. Reprod. 17: 412–416.CrossRefGoogle Scholar
  53. Koseki, Y., Zava, D.T., and Chamness, G.C., 1977a, Progesterone interaction with estrogen and antiestrogen in the rat uterus—receptor effects, Steroids 30: 169–177.CrossRefGoogle Scholar
  54. Koseki, Y., Zava, D.T., Chamness, G.C., and McGuire, W.L., 19776, Estrogen receptor translocation and replenishment by the antiestrogen tamoxifen, Endocrinology 101: 1104–1100.Google Scholar
  55. Kreitman, B., Derache, B., and Bayard, F., 1978, Measurement of corticosteroid binding globulin, progesterone and progesterone “receptor” content in human endometrium, J. Clin. Endocrinol. Metab. 47: 350–353.CrossRefGoogle Scholar
  56. Lafaye, A., and Frigot, P., 1978, Influence du véhicule sue la vitesse d’action de la progesterone au niveau de la motilite utérine chez la ratte gestante recemment biovariectomisée, Ann. Pharm. Fr. 36: 391–396.Google Scholar
  57. Leavitt, W.W., Toft, D.O., Strott, C.A., and O’Malley, B.W., 1974, A specific progesterone receptor in the hamster uterus: Physiologic properties and regulation during the estrous cycle, Endocrinology 94: 1041–1053.CrossRefGoogle Scholar
  58. Leavitt, W.W., Chen, T.J., and Allen, T.C., 1977, Regulation of progesterone receptor formation by estrogen action,Ann. N. Y. Acad. Sci. 286: 210–225.CrossRefGoogle Scholar
  59. Lerner, L.J., Brennan, D.M., Yiacas, E., de Phillipo, M., and Borman, A., 1962, Pregnancy maintenance in ovariectomized rats with 16«17a-dihydroxyprogesterone derivatives and other progestogens, Endocrinology 70: 283–287.CrossRefGoogle Scholar
  60. Luu Thi, M.T., Baulieu, E.-E., and Milgrom, E., 1975, Comparison of the characteristics and the hormonal control of endometrial and myometrial progesterone receptors, J. Endocrinol. 66: 349–356.CrossRefGoogle Scholar
  61. Madjerek, Z.S., 1972, A new bioassay of progestational activity, Acta Morphol. Neerl.Scand. 10: 259–268.Google Scholar
  62. Martel, D., and Psychoyos, A., 1978, Progesterone-induced oestrogen receptors in the rat uterus, J. Endocrinol. 76: 145–154.CrossRefGoogle Scholar
  63. Méster, J., and Baulieu, E.-E., 1975, Dynamics of oestrogen-receptor distribution between the cytosol and nuclear fractions of immature rat uterus after oestradiol administration, Biochem. J. 146: 617–623.Google Scholar
  64. Milgrom, E., Atger, M., Perrot, M., and Baulieu, E.-E., 1972, Progesterone in uterus and plasma. IV. Uterine progesterone receptors during the estrous cycle and implantation in the guinea pig, Endocrinology 90: 1071–1078.CrossRefGoogle Scholar
  65. Milgrom, E., Thi, L., Atger, M., and Baulieu, E.-E., 1973, Mechanisms regulating the concentration and conformation of progesterone receptors in the uterus, J. Biol. Chem. 248.:6366–6374Google Scholar
  66. Moguilewsky, M., and Raynaud, J.P., 1977, Progestin binding sites in the rat hypothalamus, pituitary and uterus, Steroids 30: 99–109.CrossRefGoogle Scholar
  67. Moore, R.J., and Wilson, J.D., 1973, The effect of androgenic hormones on the reduced nicotinamide adenine dinucleotide phosphate:..4–3-Ketosteroid 5a-oxidoreductase of rat ventral phosphate, Endocrinology 93:581–592.CrossRefGoogle Scholar
  68. Myatt, L., Chaudhuri, G., Elder, M.G., and Limm, L., 1978, The oestrogen receptor in the rat uterus in relation to intrauterine devices and the oestrous cycle, Biochem. J. 176: 523–529.Google Scholar
  69. Nuti, K.M., and Karavolas, H.J., 1977, Effect of progesterone and its 5a-reduced metabolites on gonadotrophin levels in estrogen-primed ovariectomized rats, Endocrinology 100:777–781.CrossRefGoogle Scholar
  70. Nutting, E.F., and Meyer, R.K., 1964, Effect of various steroids on nidation and fetal survival in ovariectomized rats, Endocrinology 74: 573–578.CrossRefGoogle Scholar
  71. Oberfield, S.E., Levine, L.S., Carey, R.M., Bejar, R., and New, M.I., 1979, Pseudohypoaldosteronism: Multiple target organ unresponsiveness to mineralocorticoid hormones, J. Clin. Endocrinol. Metab. 48: 228–234.CrossRefGoogle Scholar
  72. Olefsky, J.M., 1976, The insulin receptor: Its role in insulin resistance of obesity and diabetes, Diabetes 25:1154–1162.Google Scholar
  73. Philibert, D., and Raynaud, J.P., 1973, Progesterone binding in immature mouse and rat uterus, Steroids 22:89–98.CrossRefGoogle Scholar
  74. Philibert, D., and Raynaud, J.P., 1974, Progesterone binding in immature rabbit and guinea pig uterus, Endocrinology 94: 627–632.CrossRefGoogle Scholar
  75. Pollow, K., Schmidt-Gollwitzer, M., Borgoi, E., and Pollow, P., 1978, Influence of estrogens and gestagens on l7ß-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma, J. Mol. Med. 3: 81–89.Google Scholar
  76. Rahman, S.S.U., Billiar, R.B., and Little, B., 1975, Induction of uteroglobin in rabbits by progestogens, estradiol-17ß and ACTH, Biol. Reprod. 12: 305–314.CrossRefGoogle Scholar
  77. Rahman, S.S., Billiar, R.B., and Little, B., 1978, In vivo uterine metabolism of progesterone and 5a-pregnane-3,20-dione during the synthesis and release uteroglobin in ovariectomized steroid-treated rabbits, Endocrinology 102:1901–1908.Google Scholar
  78. Raynaud, J.P., 1977, R5020, a tag for the progestin receptor, in: Progesterone Receptors in Normal and Neoplastic Tissues ( W.L. McGuire, J.P. Raynaud, and E.-E. Baulieu, eds.), pp. 9–21, Raven Press, New York.Google Scholar
  79. Roberts, R.M., and Bazer, F.W., 1976, Phosphoprotein phosphatase activity of progesterone-induced purple glycoprotein of procine uterus, Biochem. Biophys. Res. Commun. 68: 450–455.CrossRefGoogle Scholar
  80. Rodriquez, J., Sen, K.K., Seski, J.C., Memon, M., Johnson, T.R., and Memon, K.M.J., 1979, Progesterone binding by human endometrial tissue during the proliferative and secretory phases of the menstrual cycle and by hyperplastic and carcinomatous endometrium, Am. J. Obstet. Gynecol. 133:660–665.Google Scholar
  81. Ruh, T.S., and Baudendistel, L.J., 1978, Antiestrogen modulation of the salt resistant nuclear estrogen receptor, Endocrinology 102:1838–1846.CrossRefGoogle Scholar
  82. Ruh, T.S., Baudendistel, L.J., Nicholson, W.F., and Ruh, M.F., 1979, The effects of antioestrogens on the oestrogen receptor, J. Steroid Biochem. 11: 315–322.CrossRefGoogle Scholar
  83. Saffran, J., and Loeser, B.K., 1979, Nuclear binding of guinea pig uterine progesterone receptor in cell-free preparations, J. Steroid Biochem. 10: 43–51.CrossRefGoogle Scholar
  84. Saffran, J., and Loeser, B., 1980, The effect of progesterone in vivo on the subcellular distribution and properties of progesterone receptors in guinea pig uterus, J. Steroid Biochem. 13: 589–598.CrossRefGoogle Scholar
  85. Saffran,J.,Loeser, B.K., Haas, B.M., and Stavely, H.E., 1974a, Metabolism of progesterone in rat uterus, Steroids 23:117–132.CrossRefGoogle Scholar
  86. Saffran, J., Loeser, B.K., Haas, B.M., and Stavely H.E., 1974b, Metabolism of progesterone in subcellular fractions of rat uterus, Steroids 24: 839–847.CrossRefGoogle Scholar
  87. Saffran, J., Loeser, B.K., Bohnett, S.A., and Faber, L.E., 1976, Binding of progesterone receptor by nuclear preparations of rabbit and guinea pig uterus, J. Biol. Chem. 251: 5607–5613.Google Scholar
  88. Sanyal, M.K., and Villee, C.A., 1973, Production and physiologic effects of progesterone metabolites in pregnant and pseudopregnant rats, Endocrinology 92: 83–93.CrossRefGoogle Scholar
  89. Sarff, M., and Gorski, J., 1971. Control of estrogen-binding protein concentration under basal conditions and after estrogen administration, Biochemistry 10: 2557–2563.CrossRefGoogle Scholar
  90. Scatchard, G., 1949, The attraction of proteins for small molecules and ions, Ann. N. Y. Acad. Sci. 51: 660–672.CrossRefGoogle Scholar
  91. Shapiro, S., and Forbes, S.H., 1978, Alterations in human endometrial protein synthesis during the menstrual cycle and in progesterone-stimulated organ culture, Fertil. Steril. 30: 175–180.Google Scholar
  92. Spona, J., Bieglmayer, C., and Pirker, R., 1979, Progesterone receptor in the rat anterior pituitary: Transformation and nuclear translocation, FEBS Lett. 97: 269–274.CrossRefGoogle Scholar
  93. Srivastava, A.K., 1978, Differentiation of binding proteins for D-norgestral in human uterine tissue and plasma, J. Steroid Biochem. 9: 1241–1244.CrossRefGoogle Scholar
  94. Tabei, T., Haga, H., Heinrichs, W.L., Hermann, W.L., 1974, Metabolism of progesterone by rat brain, pituitary gland and other tissues, Steroids 23: 651–666.Google Scholar
  95. Tseng, L., 1978, Steroid specificity in the stimulation of human endometrial estradiol dehydrogenase, Endocrinology 102: 1398–1403.CrossRefGoogle Scholar
  96. Verma, U., and Laumas, K., 1976, Cellular and subcellular metabolism of progesterone by human proliferative and secretory phase endometrium and myometrium, J. Steroid Biochem.7:275–282.CrossRefGoogle Scholar
  97. Vu Hai, M.T., Logeat, F., Warembourg, M., and Milgrom, E., 1977, Hormonal control of progesterone receptors, Ann. N.Y. Acad. Sci. 286: 199–209.CrossRefGoogle Scholar
  98. Vu Hai, M.T., Logeat, F., and Milgrom, E., 1978, Progesterone receptors in rat uterus: Variations in cytosol and nuclei during the estrous cycle and pregnancy, J. Endocrinol. 76: 43–48.CrossRefGoogle Scholar
  99. Walters, M.R., and Clark, J.H., 1978, Cytosol and nuclear compartmentalization of progesterone receptors of the rat uterus, Endocrinology 103: 601–609.CrossRefGoogle Scholar
  100. West, N.B., Verhage, H.G., and Brenner, R.M., 1976, Suppression of the estradiol receptor system by progesterone in the oviduct and uterus of the cat, Endocrinology 99: 1010–1016.CrossRefGoogle Scholar
  101. West, N.B., Verhage, H.G., and Brenner, R.M., 1977, Changes in nuclear estradiol receptor and cell structure during estrous cycles and pregnancy in the oviduct and uterus of cats, Biol. Reprod. 17: 138–143.CrossRefGoogle Scholar
  102. West, N.B., Norman, R.L., Sandow, B.A., and Brenner, R.M., 1978, Hormonal control of nuclear estradiol receptor content in luminal epithelium in the uterus of the golden hamster, Endocrinology 103: 1732–1741.CrossRefGoogle Scholar
  103. Whalen, R.E., Martin, J.V., and Olsen, K.L., 1975, Effect of oestrogen antagonist on hypothalamic oestrogen receptors, Nature (London) 258: 742–743.CrossRefGoogle Scholar
  104. Wu, J.T., 1972, Effect of progesterone on rat blastocyst viability during prolonged delay in implantation, Endocrinology 91: 1386–1388.CrossRefGoogle Scholar
  105. Yamamoto, K.R., and Alberts, B.M., 1976, Steroid receptors: Elements for modulation of eukaryotic transcription, Annu. Rev. Biochem.45: 721–746.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Judith Saffran
    • 1
  • Bonnie K. Loeser
    • 1
  1. 1.Department of Obstetrics and Gynecology and Department of BiochemistryMedical College of OhioToledoUSA

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