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Hormonal Modulation of Progesterone Receptors

  • Judith Saffran
  • Bonnie K. Loeser
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

According to current theories of hormone action, all the steroid hormones, including vitamin D, exert their effects in a similar way (Buller and O’Malley, 1976; Chan and O’Malley, 1976; DeLuca, 1979; Gorski and Gannon, 1976; Yamamoto and Alberts, 1976). There is general, but not universal, agreement that the hormone diffuses passively through the cell membrane (Baulieu, 1978). After entering the target cell, the hormone binds to a cytoplasmic receptor protein that is present only in target cells and that is fairly specific for the hormone. The binding is of high affinity, with equilibrium dissociation constants in the neighborhood of 10-9 M. Because there is a limited number of receptor molecules per cell, the binding of the hormone is saturable. The complex of hormone and receptor then undergoes a process of “activation” or “transformation” that enables it to enter the nucleus and bind to chromatin. This binding initiates the biochemical events that are characteristic of the hormone. There is increased transcription, resulting eventually in an increase in protein synthesis.

Keywords

Progesterone Receptor Estrous Cycle Hormonal Modulation Cytoplasmic Receptor Progesterone Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Judith Saffran
    • 1
  • Bonnie K. Loeser
    • 1
  1. 1.Department of Obstetrics and Gynecology and Department of BiochemistryMedical College of OhioToledoUSA

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