Voltage Clamp Techniques Applied to Cultured Skeletal Muscle and Spinal Neurons
For many years there has been an apocryphal story circulating around the National Institutes of Health about Dr. K. S. Cole, the developer of the voltage clamp technique (Cole, 1949, 1972). It seems that Cole was being introduced to a distinguished group of scientists in some landlocked European country. The introducer remarked that he had always felt that the voltage clamp was the “devil’s own invention” and it was his “pleasure to introduce the devil.” Well, if the voltage clamp is the devil’s own invention, then microelectrodes are the devil’s own tools when it comes to using them in voltage clamping, since they are the main source of the problems and limitations in applying the technique successfully.
KeywordsVoltage Clamp Spinal Cord Neuron Dorsal Root Ganglion Cell Current Feedback Voltage Clamp Technique
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