Neuropharmacology of Spinal Cord Neurons in Primary Dissociated Cell Culture

  • Robert L. MacDonald
  • Jeffery L. Barker


Investigation into the physiological properties of central nervous system (CNS) neurons and the pharmacological actions of clinically important drugs on the CNS have progressed in parallel over the past two decades. The suggestion that most interneuronal communication is mediated by release of chemical neurotransmitters (Krnjevic, 1974) has stimulated research into all aspects of synaptic transmission including regulation of synthesis and release of neurotransmitter from presynaptic terminals, properties of pre- and postsynaptic neurotransmitter receptors, properties of neurotransmitter-coupled ionic channels, and neuroanatomical distribution of specific neurotransmitters.


Dorsal Root Ganglion Neutral Amino Acid Intracellular Recording Spinal Cord Neuron Bathing Medium 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Robert L. MacDonald
    • 1
  • Jeffery L. Barker
    • 2
  1. 1.Department of NeurologyUniversity of MichiganAnn ArborUSA
  2. 2.Laboratory of Neurophysiology, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA

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