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2,3,7,8-Tetrachlorodibenzo-p-Dioxin

  • Brian S. Middleditch
  • Stephen R. Missler
  • Harry B. Hines

Abstract

This teratogen is so toxic that the U.S. Environmental Protection Agency recommends that analytical laboratories do not acquire the authentic material for use as a standard. It is present as an impurity in chlorinated phenols and related compounds. It is a particular hazard in waste materials produced as byproducts in the manufacture of such compounds.

Keywords

Mass Spectrometry Environmental Protection Agency Dwell Time Analytical Laboratory Electron Impact 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Selected Bibliography

  1. Fragmentation of dibenzo-p-dioxin and its derivatives under electron impact, Buu-Hoi, N. P., Saint-Ruf, G., Mangane, M., J. Heterocycl. Chem., 9(3), 691–693 (1972).CrossRefGoogle Scholar
  2. Mass spectrometry in toxicology. 1. Calculation of theoretical isotopic abundances and optimum ion dwell time for a 2,3,7,8-tetrachlorodibenzo-p-dioxin pharmacokinetic study, Reynolds, W. D., Delongchamp, R., Biomed. Mass Spectrom., 2(5), 276–278 (1975).CrossRefGoogle Scholar
  3. Identification of substitution patterns in polychlorinated dibenzo-p-dioxins (PCDDs) by mass spectrometry, Buser, H. R., Rappe, C., Chemosphere, 7(2), 199–211 (1978).CrossRefGoogle Scholar
  4. Determination of polychlorinated dibenzo-p-dioxins in biological samples by negative chemical ionization mass spectrometry, Hass, J. R., Friesen, M. D., Harvan, D. J., Parker, C. E., Anal Chem., 50(11), 1474–1479 (1978).CrossRefGoogle Scholar
  5. Chlorinated benzyl phenyl ethers: a possible interference in the determination of chlorinated dibenzo-p-dioxins in 2,4,5-trichlorophenol and its derivatives, Shadoff, L. A., Blaser, W. W., Kocher, C. W., Fravel, H. G., Anal. Chem., 50(11), 1586–1588 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Brian S. Middleditch
    • 1
  • Stephen R. Missler
    • 1
  • Harry B. Hines
    • 1
  1. 1.University of HoustonHoustonUSA

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