Microbial Iron Uptake and the Antimicrobial Properties of the Transferrins

  • Anatoly Bezkorovainy
Part of the Biochemistry of the Elements book series (BOTE, volume 1)


Most if not all microorganisms including the fungi require ferric iron for growth, where iron concentration in the medium must be between 0.4 and 4 × 10−6 M (Weinberg, 1978). Yet, because the solubility product of ferric hydroxide, which is present at pH values of about 6 and above, is near 4 × 10−36, ferric iron concentrations in the growth medium are near 10−15 M. Moreover, many biological fluids contain one or several proteins of the transferrin class, which have association constants of around 1036 with respect to iron. Indeed, it has been said that the frequency of iron dissociation from human serum transferrin in the absence of small chelating agents or a specific biological system designed to abstract iron from this protein is one iron atom per 10,000 years (see Chapter 4). To overcome such obstacles, microorganisms have evolved the ability to synthesize small-molecular-weight chelators, which seek out iron in the environment and return it to the microorganism. Such chelators are termed siderochromes or, alternately, siderophores. It has been argued that the latter is the preferred term (Neilands, 1977), and we shall use it in this chapter.


Human Milk Iron Overload Ferric Iron Mycobacterium Smegmatis Picolinic Acid 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Anatoly Bezkorovainy
    • 1
  1. 1.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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