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Ferrokinetics

  • Anatoly Bezkorovainy
Part of the Biochemistry of the Elements book series (BOTE, volume 1)

Abstract

Ferrokinetics is a term generally applied to the tracing of radioactive iron following its parenteral administration to an animal or human patient. This involves the mixing of isotopic ferrous or ferric iron in the citrate form with a serum sample to assure its binding with transferrin, injection into the organism, and the measuring of the levels of radioactive iron in plasma as a function of time. When the logarithm of plasma radioactive iron is plotted against time, a so-called iron decay curve is obtained which can yield valuable information in regard to the fate of the injected iron in the organism. In addition, various areas on the surface of the organism can be monitored for radioactive iron. This provides an estimate of radioactive iron moving into internal areas in the vicinity of such surface areas. The organs of interest are the liver, spleen, and bone marrow. In the case of the last, radioactivity present over the sacral region of the spinal column is believed to represent iron moving into the bone marrow.

Keywords

Hemolytic Anemia Iron Metabolism Polycythemia Vera Plasma Iron Iron Pool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Balasch, J., and Planas, J., 1972. Iron metabolism in duck and turkey, Rev. Esp. Fisiol. 28: 125–128.PubMedGoogle Scholar
  2. Barosi, G., Cazzola, M., Morandi, S., Stefanelli, M., and Perugini, S., 1978. Estimation of ferrokinetic parameters by a mathematical model in patients with primary acquired sideroblastic anemia, Br. J. Haematol. 39: 409–423.PubMedCrossRefGoogle Scholar
  3. Cavill, I., and Jacobs, A., 1971. Iron kinetics in the skin, Br. J. Haematol. 20: 145–153.PubMedCrossRefGoogle Scholar
  4. Cavill, I., and Ricketts, C., 1974. The kinetics of iron metabolism, in Iron in Biochemistry and Medicine, A. Jacobs and M. Worwood (eds.), Academic Press, New York, pp. 613–647.Google Scholar
  5. Cavill, I., and Ricketts, C., 1978. Erythropoiesis and iron kinetics, Br. J. Haematol. 38: 433–437.PubMedCrossRefGoogle Scholar
  6. Cavill, I., Ricketts, C., Napier, J. A. F., and Jacobs, A., 1977. Ferrokinetics and erythropoiesis in man: red cell production and destruction in normal and anemic subjects, Br. J. Haematol. 35: 33–40.PubMedCrossRefGoogle Scholar
  7. Cook, J. D., Marsaglia, G., Eschbach, J. W., Funk, D. D., and Finch, C. A., 1970. Ferrokinetics: A biologic model for plasma iron exchange in man, J. Clin. Invest. 49: 197–205.PubMedCrossRefGoogle Scholar
  8. Douglas, T. A., Renton, J. P., and Watts, C., 1971. Placental transfer of iron in the rabbit, Br. J. Haematol. 20: 185–194.PubMedCrossRefGoogle Scholar
  9. Finch, C. A., Denbelbeiss, K., Cook, J. D., Eschbach, J. W., Harker, L. A., Funk, D. D., Marsaglia, G., Hillman, R. S., Slichter, S., Adamson, J. W., Ganzoni, A., and Giblett, E. R., 1970. Ferrokinetics in man, J. Clin Invest. 49: 17–53.Google Scholar
  10. Hahn, P. F., Bale, W. F., Lawrence, E. O., and Whipple, G. H., 1939. Radioactive iron and its metabolism in anemia; its absorption, transportation and utilization, J. Exp. Med. 69: 739–753.PubMedCrossRefGoogle Scholar
  11. Hosain, F., Marsaglia, G., and Finch, C. A., 1967. Blood ferrokinetics in normal man, J. Clin. Invest. 46: 1–9.PubMedCrossRefGoogle Scholar
  12. Huff, R. L., Hennessy, T. G., Austin, R. E., Garcia, J. F., Roberts, B. M., and Lawrence, J. H., 1950. Plasma and red cell iron turnover in normal subjects and in patients having various hematologic disorders, J. Clin. Invest. 29: 1941–1052.CrossRefGoogle Scholar
  13. Huff, R. L., Elmlinger, P. J., Garcia, J. F., Oda, J. M., Cockrell, M. C., and Lawrence, J. H., 1951. Ferrokinetics in normal persons and in patients having various erythropoietic disorders, J. Clin. Invest. 30: 1512–1526.PubMedCrossRefGoogle Scholar
  14. Marsaglia, G., 1963. Stochastic analysis of multicompartment systems, Math. Note 313, Di- 82-0280, Boeing Scientific Research Laboratories, Seattle, quoted by Hosain., 1967, and by Finch., 1970.Google Scholar
  15. Marx, J. J. M., 1979. Normal iron absorption and decreased red cell iron uptake in the aged, Blood 53: 204–211.PubMedGoogle Scholar
  16. Najean, Y., Cacchione, R., Castro-Malaspina, H., and Dresch, C., 1978. Erythrokinetic studies in myelofibrosis: Their significance for prognosis, Br. J. Haematol. 40: 205–217.PubMedCrossRefGoogle Scholar
  17. Noyes, W. D., Hosain, F., and Finch, C. A., 1964. Incorporation of radioiron into marrow heme, J. Lab. Clin. Med. 64: 574–580.PubMedGoogle Scholar
  18. Pollycove, M., 1978. Hemochromatosis, in The Metabolic Basis of Inherited Disease, J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson (eds.), McGraw-Hill, New York, pp. 1127–1164.Google Scholar
  19. Pollycove, M., and Mortimer, R., 1961. The quantitative determinants of iron kinetics and hemoglobin synthesis in human subjects, J. Clin. Invest. 40: 753–782.PubMedCrossRefGoogle Scholar
  20. Ricketts, C., Jacobs, A., and Cavill, I., 1975. Ferrokinetics and erythropoiesis in man: The measurement of effective erythropoiesis, ineffective erythropoiesis, and red cell life span using 59Fe, Br. J. Haematol. 31: 65–75.PubMedCrossRefGoogle Scholar
  21. Ricketts, C., Cavill, I., Napier, J. A. F., and Jacobs, A., 1977. Ferrokinetics and erythropoiesis in man: An evaluation of ferrokinetic measurements, Br. J. Haematol. 35: 41–47.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Anatoly Bezkorovainy
    • 1
  1. 1.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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