Ferrokinetics is a term generally applied to the tracing of radioactive iron following its parenteral administration to an animal or human patient. This involves the mixing of isotopic ferrous or ferric iron in the citrate form with a serum sample to assure its binding with transferrin, injection into the organism, and the measuring of the levels of radioactive iron in plasma as a function of time. When the logarithm of plasma radioactive iron is plotted against time, a so-called iron decay curve is obtained which can yield valuable information in regard to the fate of the injected iron in the organism. In addition, various areas on the surface of the organism can be monitored for radioactive iron. This provides an estimate of radioactive iron moving into internal areas in the vicinity of such surface areas. The organs of interest are the liver, spleen, and bone marrow. In the case of the last, radioactivity present over the sacral region of the spinal column is believed to represent iron moving into the bone marrow.
KeywordsHemolytic Anemia Iron Metabolism Polycythemia Vera Plasma Iron Iron Pool
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