Tissue Iron and an Overview on Nonheme Iron Biochemistry

  • Anatoly Bezkorovainy
Part of the Biochemistry of the Elements book series (BOTE, volume 1)


It is difficult to decide exactly where a treatise on nonheme iron metabolism should begin, especially in view of the fact that heme and nonheme iron biology are so intricately interconnected. It is perhaps prudent to introduce some basic vocabulary and concepts in an abbreviated form and to present a brief unified overview of iron metabolism which can serve as a framework upon which the more detailed material of this and the following chapters can be constructed.


Iron Content Iron Deficiency Anemia Serum Iron Iron Metabolism Body Iron 
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  1. Altman, P. L. (ed.), 1959. Handbook of Circulation, Saunders, Philadelphia, pp. 38–45.Google Scholar
  2. Altman, P. L., and Dittmer, D. S. (eds.), 1961. Blood and Other Body Fluids, Federation of American Societies for Experimental Biology (FASEB), Washington, D.C.Google Scholar
  3. Altman, P. L., and Dittmer, D. S. (eds.), 1968. Metabolism, FASEB, Bethesda, Md.Google Scholar
  4. Altman, P. L., and Dittmer, D. S. (eds.), 1972. Biology Data Book, Vol. I, 2nd ed., FASEB, Bethesda, Md., pp. 407–409.Google Scholar
  5. Altman, P. L., and Dittmer, D. S. (eds.), 1974. Biology Data Book, Vol. Ill, 2nd ed., FASEB, Bethesda, Md.Google Scholar
  6. Altman, P. L., and Dittmer, D. S. (eds.), 1977. Human Health and Disease, FASEB, Bethesda, Md., p. 165.Google Scholar
  7. Blaxter, K. L., 1961. Lactation and the growth of the young, in Milk: The Mammary Gland and Its Secretion, Vol II, S. K. Kon and A. T. Cowie (eds.), Academic Press, New York, pp. 344–347.Google Scholar
  8. Bleijenberg, B. G., von Eijk, H. G., and Leijnse, B. 1971. The determination of non-heme iron and transferrin in cerebrospinal fluid, Clin. Chim. Acta 31: 277–281.PubMedCrossRefGoogle Scholar
  9. Burman, D., 1974. Iron metabolism in infancy and childhood, in Iron in Biochemistry and Medicine, A. Jacobs, and M. Worwood (eds.), Academic Press, New York, p. 552.Google Scholar
  10. Damm, H. C., and King, J. W. (eds.), 1965. Handbook of Clinical Laboratory Data, Chemical Rubber Publishing Company, Cleveland, p. 291.Google Scholar
  11. Drabkin, D. L., 1951. Metabolism of the hemin chromoproteins, Physiol. Rev. 31: 345–431.PubMedGoogle Scholar
  12. Engel, R. H., and Pribor, H. C., 1978. Serum ferritin: A convenient measure of body iron stores, Lab. Manage. Oct.: 31–34.Google Scholar
  13. Fairbanks, V. F., Fahey, J. L., and Bentler, E. (eds.), 1971. Clinical Disorders of Iron Metabolism, Grune & Stratton, New York, pp. 1–41.Google Scholar
  14. Fridovich, I., 1975. Superoxide dismutases, Annu. Rev. Biochem. 44: 147–159.PubMedCrossRefGoogle Scholar
  15. Frieden, E., 1974. The evolution of metals as essential elements, in Protein-Metal Interactions, M. Friedman (ed.), Plenum, New York, pp. 1–32.Google Scholar
  16. Garrison, F. H. (ed.), 1929. An Introduction to the History of Medicine, Saunders, Philadelphia.Google Scholar
  17. George, D. W., and Dessauer, H. C., 1970. Immunological correspondence of transferrins and the relationships of colubrid snakes, Comp. Biochem. Physiol. 33: 611–621.Google Scholar
  18. Guthrie, D. (ed.), 1946. A History of Medicine, Lippincott, Philadelphia.Google Scholar
  19. Haeckel, R., Haindl, H., Hultsch, E., Mariss, P., and Oellerrich, M., 1973. Comparison of 8 different colorimetric, radiochemical, and immunological procedures for the determination of iron binding capacity, Z. Klin. Chem. Klin. Biochem. 11: 529–534.PubMedGoogle Scholar
  20. Heilmeyer, L., and Plötner, K., 1937. Das Serumeisen und die Eisenmangelkrankheit (Path-ogenese, Symptomatologie, und Therapie), G. Fischer, Jena, Germany.Google Scholar
  21. Ichida, T., Osaka, T., and Kojima, K., 1968. A simple method for the determination of serum iron, Clin. Chim. Acta 22: 271–275.PubMedCrossRefGoogle Scholar
  22. International Committee for Standardization in Hematology, 1978a. The measurement of total and unsaturated iron-binding capacity in serum, Br. J. Haematol. 38: 281–294.CrossRefGoogle Scholar
  23. International Committee for Standardization in Hematology, 1978b. Recommendations for measurement of serum iron in human blood, Br. J. Haematol. 38: 291–294.CrossRefGoogle Scholar
  24. Itzhaki, R. F., and Belcher, E. H., 1961. Studies on plasma iron in the rat. II. Plasma iron concentration and plasma iron-binding capacity. Arch. Biochem. Biophys. 92: 74–80.PubMedCrossRefGoogle Scholar
  25. Jordan, S. M., Kaldor, I., and Morgan, E. H., 1967. Milk and serum iron and iron-binding capacity in the rabbit, Nature (London) 215: 76–77.CrossRefGoogle Scholar
  26. Kaneko, J. J., 1971. Iron metabolism, in Clinical Biochemistry of Domestic Animals, J. J. Kaneko and C. E. Cornelius (eds.), Academic Press, New York, p. 388.Google Scholar
  27. Martinek, R. G., 1973. Simplified determination of serum iron and binding capacity by nitroso-R-salt without deproteinization, Clin. Chim. Acta 43: 73–80.CrossRefGoogle Scholar
  28. Marx, J. J. M., 1979. Normal iron absorption and decreased red cell iron uptake in the aged, Blood 53: 204–211.PubMedGoogle Scholar
  29. McCay, C. M. (ed.), 1973. Notes on the History of Nutrition Research, Hans Huber, Berne, pp. 156–171.Google Scholar
  30. McLaren, D. S., and Burman, D. (eds.), 1976. Textbook of Paediatric Nutrition, Churchill Livingstone, Edinburgh, p. 59.Google Scholar
  31. Melby, E. C., Jr., and Altman, N. H. (eds.), 1974. Handbook of Laboratory Animal Science, Vol. II, CRC Press, Inc., Cleveland, pp. 378–379.Google Scholar
  32. Mettler, C. C. (ed.), 1947. History of Medicine, McGraw-Hill, Inc., Blakiston Division, New York.Google Scholar
  33. Moore, C., and Dubach, R., 1962. Iron, in Mineral Metabolism, Vol. 2B, C. L. Comar and F. Bronner (eds.), Academic Press, New York, pp. 287–348.Google Scholar
  34. Ness, A. T., and Dickerson, H. C., 1965. The determination of serum iron by nitroso-R-salt without deproteinization, Clin. Chim. Acta 12: 579–588.PubMedCrossRefGoogle Scholar
  35. Osterberg, R., 1974. Origins of metal ions in biology, Nature (London) 249: 382–384.CrossRefGoogle Scholar
  36. Picciano, M. F., and Guthrie, H. A., 1976. Copper, iron and zinc contents of mature human milk, Am. J. Clin. Nutr. 29: 242–254.PubMedGoogle Scholar
  37. Planas, J., 1967. Serum iron transport in the fowl and the mammal, Nature (London) 215: 289–290.CrossRefGoogle Scholar
  38. Pollycove, M., 1978. Hemochromatosis, in The Metabolic Basis of Inherited Disease, J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson (eds.), McGraw-Hill, New York, p. 1128.Google Scholar
  39. Pronk, C., Oldenziel, H., and Lequin, H. C., 1974. A method for determination of serum iron, total iron binding capacity, and iron in urine by atomic absorption spectropho-tometry with manganese as internal standard, Clin. Chim. Acta 50: 35–41.PubMedCrossRefGoogle Scholar
  40. Ramsay, W. N. M., 1958. Plasma iron, Adv. Clin. Chem. 1: 12–19.Google Scholar
  41. Schilt, A. A., and Hoyle, W. C., 1967. Improved sensitivity and selectivity in the spectrophotometric determination of iron by use of a new ferroin-type reagent, Anal. Chem. 39: 114–117.CrossRefGoogle Scholar
  42. Schmidt, J. E. (ed.), 1959. Medical Discoveries, Charles Thomas, Springfield, 111.Google Scholar
  43. Searcy, R. L. (ed.), 1969. Diagnostic Biochemistry, McGraw-Hill, New York, p. 328.Google Scholar
  44. Siimes, M. A., Vuori, E., and Kuitanen, P., 1979. Breast milk iron—a declining concentration during the course of lactation, Acta Paediatr. Scand. 68: 29–31.PubMedCrossRefGoogle Scholar
  45. Tartour, G., 1973. The variation with age of the serum iron concentration and iron-binding capacity in Zebu cattle, Res. Vet. Sci. 15: 389–391.Google Scholar
  46. Tavenier, P., and Hellendoorn, H. B. A., 1969. A comparison of serum iron values determined by atomic absorption and by some spectrophotometric methods, Clin. Chim. Acta 23: 47–52.PubMedCrossRefGoogle Scholar
  47. Tietz, N. W. (ed.), 1976. Fundamentals of Clinical Chemistry, 2nd ed., Saunders, Philadelphia, p. 929.Google Scholar
  48. Tipton, I. H., and Cook, M. J., 1963. Trace elements in human tissue, Part II, Adult subjects from the United States, Health Phys. 9:103–143, quoted by M. Worwood, The clinical biochemistry of iron, Semin. Hematol. 14: 3–30, 1977.PubMedCrossRefGoogle Scholar
  49. Underwood, E. J. (ed.), 1977a. Trace Elements in Human and Animal Nutrition, Academic Press, New York, pp. 13–55.Google Scholar
  50. Underwood, E. J. (ed.), 1977b. Trace Elements in Human and Animal Nutrition, Academic Press, New York, p. 14.Google Scholar
  51. Van Eijk, H. G., and Kroos, M. J., 1978. The iron status in healthy individuals aged from 18-25 years, Folia Haematol. ( Leipzig ) 105: 93–95.Google Scholar
  52. Van Laucker, J. L. (ed.), 1975. Molecular and Cellular Mechanisms in Disease, Spring, Berlin, p. 365.Google Scholar
  53. Van Vugt, H., Van Gool, J., Ladiges, N. C. J. J., and Boers, W., 1975. Lactoferrin in rabbit bile: Its relation to iron metabolism, Q. J. Exp. Physiol. 60: 79–88.Google Scholar
  54. Weippl, G., Pantlitschko, M., Bauer, P., and Lund, S., 1973. Serumeisen-Normalwerte und statistische Verteilung der Einzelwerte bei Mann und Frau, Blut 27: 261–269.PubMedCrossRefGoogle Scholar
  55. Werkman, H. P. T., and Trijbels, J. M. F., and Schretlen, E. D. A. M., 1974. The “short-term” iron rhythm, Clin. Chim. Acta 53: 65–68.PubMedCrossRefGoogle Scholar
  56. Worwood, M., 1977. The clinical biochemistry of iron, Semin. Hematol. 14: 3–30.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Anatoly Bezkorovainy
    • 1
  1. 1.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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