The Genetics of B-Cell Alloantigens
Reagent development over the last several years has made possible the identification of a series of alloantigens expressed preferentially on B lymphocytes (Mann et al., 1975a; Winchester et al., 1975). These antigens may be considered differentiation antigens in that other subpopulations appear to express the antigens detected readily on B cells. These subpopulations are monocytes and, under the right circumstances, T cells (Mann and Sharrow, 1980). The role of the B-cell antigens in the immune response remains to be determined; however, if these antigens are similar to the Ia antigens of mice, they may be implicated in or identify immune response genes.
KeywordsSystemic Lupus Erythematosus Reactivity Pattern Carbonyl Iron Normal Human Serum Immune Response Gene
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