The DR Region of HLA

Serological Analysis
  • A. H. Johnson
  • R. Hartzman
  • D. B. Amos


Following the finding by van Leeuwen et al. (1973) that antisera that blocked mixed-lymphocyte reactivity (MLR) were reactive with only a small proportion of blood lymphocytes, many other investigators have developed methods for examining and categorizing the antigen(s) involved. These antigens are present on B lymphocytes and have been designated HLA-DR for HLA-D related. Technical developments include the removal of antibodies to HLA-A, -B and -C allelic products by absorption with platelets that do not have DR (B-cell) antigens (van Rood et al., 1975a) and enrichment of the lymphocyte population for “B” lymphocytes by adsorption onto anti-F(ab’)2-coated surfaces (Mage et al., 1977; Grier et al., 1977), differential sedimentation after rosetting T lymphocytes with sheep red cells (van Rood et al., 1975a; Terasaki et al., 1978), or differential adherence to nylon wool (Danilovs et al., 1979; Lowry et al., 1978).


Lymphoblastoid Cell Line Serological Analysis Allelic Series Nylon Wool Reference Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • A. H. Johnson
    • 1
  • R. Hartzman
    • 1
    • 2
  • D. B. Amos
    • 3
  1. 1.Department of Pediatrics, Division of Immunologic OncologyGeorgetown University School of MedicineUSA
  2. 2.Naval Medical Research InstituteBethesdaUSA
  3. 3.Division of Immunology, Department of MicrobiologyDuke University Medical CenterDurhamUSA

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