Hybrid Sterility Gene Located in the T/t-H-2 Supergene on Chromosome 17

  • Jiří Forejt


Recent advances in genetic analysis of the major histocompatibility systems of various species and the first successful attempts at molecular dissection of their products contrast with the limited knowledge concerning the biological function of this particular part of the eukaryotic genome. The major histocompatibility system of the mouse, the H-2 system, adjoins closely the T/t genetic complex in chromosome 17. The T/t complex occupies a region of the chromosome 20 times longer than that pertaining to the H-2 system, and controls a variety of vital functions necessary for the development of the organism and survival of the species.


Male Sterility Male Fertility House Mouse Hybrid Sterility Chiasma Frequency 
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© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Jiří Forejt
    • 1
  1. 1.Institute of Molecular GeneticsCzechoslovak Academy of SciencesPrague 4Czechoslovakia

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