Expression of Syngeneic and Allogeneic H-2 Antigens on Tumor Cells
It is now well established that the major histocompatibility system (MHS), Ly, and other alloantigenic systems play important roles in cell-cell interactions, which are particularly relevant in immune reactivity. For example, I-region gene products are involved in the presentation of antigen by macrophages and may be part of antigen-specific and -nonspecific factors that are released by helper and suppressor cells, respectively. In contrast, T-cell in vitro cytotoxicity appears to be dependent on the sharing of H-2K/D-like gene products between target and effector cells in specific instances. This appears to be true for virally infected and chemically modified cells and for effector cells sensitized against the H-Y antigen and a variety of non-H-2 antigens including certain tumor-associated antigens. Any modification of the antigenic profile of effector or target cells, or both, may thus substantially influence the outcome of immune reactivity (for references, see Snell, 1979).
KeywordsCongeneic Strain Antigenic Profile Iymph Node Syngeneic Cell London Hospital Medical College
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