Expression of Syngeneic and Allogeneic H-2 Antigens on Tumor Cells

  • Hilliard Festenstein
  • Wilhelm Schmidt
  • Carla Testorelli


It is now well established that the major histocompatibility system (MHS), Ly, and other alloantigenic systems play important roles in cell-cell interactions, which are particularly relevant in immune reactivity. For example, I-region gene products are involved in the presentation of antigen by macrophages and may be part of antigen-specific and -nonspecific factors that are released by helper and suppressor cells, respectively. In contrast, T-cell in vitro cytotoxicity appears to be dependent on the sharing of H-2K/D-like gene products between target and effector cells in specific instances. This appears to be true for virally infected and chemically modified cells and for effector cells sensitized against the H-Y antigen and a variety of non-H-2 antigens including certain tumor-associated antigens. Any modification of the antigenic profile of effector or target cells, or both, may thus substantially influence the outcome of immune reactivity (for references, see Snell, 1979).


Congeneic Strain Antigenic Profile Iymph Node Syngeneic Cell London Hospital Medical College 
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  1. Abstracts, Workshop on H-2 Antigens, London, England, April 29–May 3, 1979, Immunogenetics 9:305–326, 1979.Google Scholar
  2. Amos, D.B., 1971, Genetic control of the human HL-A histocompatibility system: Alternatives to the two sublocus hypothesis, Transplant. Proc. 3:71.PubMedGoogle Scholar
  3. Cikes, M., and Friberg, S., Jr., 1971, Expression of H-2 and Moloney leukaemia virus-determined cell-surface antigens in synchronized cultures of a mouse cell line, Proc. Natl. Acad. Sci. U.S.A. 6:566.CrossRefGoogle Scholar
  4. Festenstein, H., 1978, Natural Resistance Systems against Foreign Cells, Tumors and Microbes (G. Cudkowicz, M. Landy, and G.M. Shearer, eds.), pp. 223–232. Academic Press, New York.Google Scholar
  5. Festenstein, H., Schmidt, W., Testorelli, C., DeGiorgi, L., Marelli, O., Matossian-Rogers, A., and Atfield, G., 1979a, Immunogenetic and immunochemical studies of H-2 antigens of foreign haplotypes on tumor cells,J. Immunogenet. 6:263.CrossRefGoogle Scholar
  6. Festenstein, H., Schmidt, W., Matossian-Rogers, A., deGiorgi, L., and Testovelli, C., 1979b, Nature of extra H-2 like antigenic specificities on tumor cells, in: Current Trends in Tumour Immunology (S. Ferrone, S. Govini, R. B. Herberman and R. A. Reisfeld, eds.), pp. 299–307, Garland STPM Press, New York.Google Scholar
  7. Finberg, R., Burakoff, S.J., Cantor, H., and Benaceraff, B, 1978, Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells, Proc. Natl. Acad. Sci. U.S.A. 75:5145.PubMedCrossRefGoogle Scholar
  8. Garrido, F., Schirrmacher, V., and Festenstein, H., 1976a, H-2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection, Nature (London) 259:228.CrossRefGoogle Scholar
  9. Garrido, F., Festenstein, H., and Schirrmacher, V., 1976, Further evidence for derepression of H-2 and Ia-like specificities of foreign haplotypes in mouse tumor cell lines, Nature (London) 261:705.CrossRefGoogle Scholar
  10. Garrido, F., Schirrmacher, V., and Festenstein, H., 1977a, Studies on H-2 specificities on mouse tumor cells by a new microradioassay,J. Immunogenet. 4:15.CrossRefGoogle Scholar
  11. Garrido, F., Schmidt, W., and Festenstein, H., 1977b, Immunogenetic studies on Meth.A-vaccinia tumor cells in vivo and in vitro, J. Immunogenet. 4:115.CrossRefGoogle Scholar
  12. Hämmerling, G.J., Lemke, H., Hämmerling, U., Hohmann, C., Wallich, R., and Rajewsky, K., 1978, Monoclonal antibodies against murine cell surface antigens: Anti-H-2, anti-Ia and anti-T cells antibodies, in: Current Topics in Microbiology and Immunology, Vol. 81 (F. Melchers, M. Potter, and N. Werner, eds.), pp. 100–106, Springer-Verlag, Berlin, Heidelberg, New York.Google Scholar
  13. Jerne, N.K., 1971, The somatic generation of immune recognition, Eur. J. Immunol. 1:1.PubMedCrossRefGoogle Scholar
  14. Klein, J., 1973, H-2 mutations, Adv. Immunol. 26:55.CrossRefGoogle Scholar
  15. Levy, J.P., 1974, Antigens associated with C type RNA virus induced tumors, in: Progress in Immunology, Vol. 3 (L. Brent and J. Holborow eds.), pp. 299–303, American Elsevier, New York.Google Scholar
  16. Nathenson, S.G., Brown, J.L., Ewenstein, B.M., Nisizawa, T., Sears, D.W., and Freed, J.H., 1977, Structural differences between parent and variant H-2K glycoproteins from mouse strains carrying H-2 gene mutations, Cold Spring Harbor Symp. Quant. Biol. 41:343.PubMedCrossRefGoogle Scholar
  17. Old, E.J., and Stockert, E., 1977, Immunogenetics of cell surface antigens of mouse leukaemia, Annu. Rev. Genet 17:127.CrossRefGoogle Scholar
  18. Old, E.J., Boyse, E.A., and Stockert, E., 1965, The G (Gross) leukaemia antigen, Cancer Res. 25:813–819.PubMedGoogle Scholar
  19. Schmidt, W., and Festenstein, H., 1980, Serological and immunochemical studies of H-2 allospecificities on K36, a syngeneic tumour of AKR,J. Immunogenetics 7:7.CrossRefGoogle Scholar
  20. Schmidt, W., Atfield, G., and Festenstein, H., 1979, Loss of H-2Kk gene product(s) from an AKR spontaneous leukaemia, Immunogenetics 8:311.CrossRefGoogle Scholar
  21. Simonsen, M., 1970, On the nature and measurement of antigenic strength, Transplant. Rev. 3:22.Google Scholar
  22. Simpson, E., Mobraaten, L., Chandler, P., 1978, Cross-reactive cytotoxic responses. H-2 restricted are more specific than anti-H-2 responses, J. Exp. Med. 148:1478.PubMedCrossRefGoogle Scholar
  23. Snell, G.D., 1979, The major histocompatibility complex: Its evolution and involvement in cellular immunity, Harvey Lect. Google Scholar
  24. Testorelli, C., Marelli, O., Schmidt, W., and Festenstein, H., 1980, Changes in H-2 antigen expression on a murine spontaneous leukaemia (K36) detected by cell-mediated cytotoxicity assay, J. Immunogenet. 7:19.PubMedCrossRefGoogle Scholar
  25. Workshop Issue, 1980, H-2 Antigens: Genetic Control and Expression on Normal, Tumour and Virally Infected Cells, London, England, April 29-May, 3, 1979, J. Immunogenet. 7.Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Hilliard Festenstein
    • 1
  • Wilhelm Schmidt
    • 1
  • Carla Testorelli
    • 1
  1. 1.Department of ImmunologyThe London Hospital Medical CollegeLondon E1, 2ADEngland

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