Genetic Organization, Tissue Expression, and Functional Role of Murine Ia Antigens

  • Chella S. David
  • Kirk W. Beisel
  • Christopher J. Krco
  • William P. Lafuse


The H-2 complex, the major histocompatibility complex (MHC) of the mouse, is an extremely polymorphic and pleiotrophic group of loci located in the middle section of chromosome 17 (Fig. 1) (Klein, 1975). The genetic map of the H-2 complex has traditionally been defined by the H-2K locus at the centromeric end and by the H-2D locus at the telomeric end. The serological markers for the H-2K and the H-2D regions are the classic H-2 transplantation antigens with a molecular weight of 45,000 that convey genetic restriction as targets for subpopulations of cytotoxic T cells (Zinkernagel and Doherty, 1974). The H-2D region gene codes for two independent molecular products of the D and L loci (Neuport-Sautes et al., 1978; Hansen and Sachs, 1978). The order of the H-2L and H-2D loci is not known at present and will be referred to as D(L). The H-2G region is defined by an erythrocyte-specific antigen, H-2.7 (David et al., 1975a; Klein et al., 1975). Recent studies show that this antigen is also found in the serum of H-2.7-positive strains (L. Brown, personal communication) and that it could be one of the components of the complement system (Beisel, unpublished data). The S region codes for genes controlling the quantitative levels of the C’4 complement component (Meo et al., 1975; Shreffler, 1976) as well as a sex-limited allotypic variant (Slp) of the C’ 4 molecule (Passmore and Shreffler, 1970; Roos et al., 1978).


Major Histocompatibility Complex Suppressor Factor Private Specificity 17th Chromosome Helper Factor 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Chella S. David
    • 1
  • Kirk W. Beisel
    • 1
  • Christopher J. Krco
    • 1
  • William P. Lafuse
    • 1
  1. 1.Department of ImmunologyMayo Clinic and Medical SchoolRochesterUSA

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