Are D and DR Two Distinct Entities?

  • Jean Dausset


It is only recently that the human HLA-D locus has been recognized and analyzed. Bach and Amos (1967) and Yunis and Amos (1971) were the first to explain the “abnormal” mixed-lymphocyte reaction (MLR) between HLA-identical siblings by the existence of recombination between the classic A and B HLA loci and a “new” locus now called HLA-D.


Major Histocompatibility Complex Distinct Entity Tissue Antigen Functional Dissociation Stimulate Product 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Jean Dausset
    • 1
  1. 1.Research Unit INSERM U93, Centre HayemHôpital Saint-LouisParis Cedex 10France

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