Antigenic Structures of HLA(A,B,C) Antigens
HLA(A,B,C) antigens,* i.e., the human classic histocompatibility antigens, form a unique group of human cell-surface antigens that are controlled by allelic genes of three loci, HLA-A, HLA-B, and HLA-C, located in the human major histocompatibility complex. It is a highly polymorphic alloantigen system, and a total of 50 allospecificities have been defined. The alloantigens in this system are composed of two noncova-lently bound component peptides, one of 43,000 daltons and another of 11,000 daltons (Rask et al., 1974; Strominger et al., 1974; Tanigaki and Pressman, 1974). The 11,000-dalton component is a simple protein and is known to be identical to human β 2-microglobulin (Grey et al., 1973; Nakamuro et al., 1973; Tanigaki et al., 1973; Peterson et al., 1974). No allospecificity has been found in this portion of any HLA antigens. The 43,000-dalton component is a glycoprotein and carries a determinant(s) that is responsible for the HLA(A,B,Q allospecificity and is indeed the HLA gene product (Nakamuro et al., 1975a). This alloantigenic component of the HLA(A,B,C) alloantigens is referred to as the “HLA(A,B,C) component” in this chapter.
KeywordsNormal Rabbit Serum Normal Human Serum Cyanogen Bromide Antigenic Structure Radioactive Peak
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- Nakamuro, K., Tanigaki, N., and Pressman, D., 1975b, Common antigenic structures of HL-A antigens. VI. Common antigenic determinants located on the 33,000-dalton alloantigenic fragment portion of papain-solubilized HL-A molecules, Immunology 29:1119.Google Scholar