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Complete Primary Structure of Human Histocompatibility Antigen HLA-B7

Its Evolutionary and Functional Implications
  • Jack L. Strominger
  • Victor H. Engelhard
  • Braydon C. Guild
  • Thomas G. Kostyk
  • Doron Lancet
  • José A. Lopez de Castro
  • Harry T. Orr
  • Peter Parham
  • Hidde L. Ploegh
  • Jordan S. Pober

Abstract

Tissue grafts cannot be exchanged successfully in the absence of immuno-suppression, except between syngeneic strains or identical twins. From a biochemical standpoint, each individual of a species carries on the surface of its cells substances now known to be glycoproteins that are recognized by every other individual of that species as foreign. These glycoproteins are the products of a highly polymorphic genetic system, first discovered through mouse-breeding studies. Largely through the efforts of Peter Gorer in England and George Snell in Bar Harbor, a region was identified, called the H-2 region, differences at which are the two major histocompatibility antigens, called H-2K and H-2D, were products of two genetic loci in the H-2 region on the 17th mouse chromosome. Subsequently, a variety of othr loci have been identified that are in some manner involved in graf rejection or acceptance. This region is organized similarly in all species that have been examined and is now called the major histocompatibility complex (MHC).

Keywords

Major Histocompatibility Complex Histocompatibility Antigen Semliki Forest Virus Complete Amino Acid Sequence Immunoglobulin Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Jack L. Strominger
    • 1
  • Victor H. Engelhard
    • 1
  • Braydon C. Guild
    • 1
  • Thomas G. Kostyk
    • 1
  • Doron Lancet
    • 1
  • José A. Lopez de Castro
    • 1
  • Harry T. Orr
    • 1
  • Peter Parham
    • 1
  • Hidde L. Ploegh
    • 1
  • Jordan S. Pober
    • 1
  1. 1.Biological LaboratoriesHarvard UniversityCambridgeUSA

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