Structure of H-2 Major Histocompatibility Complex Products

Recent Studies on the H-2Kb Glycoprotein and on the H-2Kb MHC Mutants
  • Stanley G. Nathenson
  • Bruce M. Ewenstein
  • Hiroshi Uehara
  • John M. Martinko
  • John E. Coligan
  • Thomas J. Kindt


The immune response is a reaction to a foreign or nonself substance. Intricately involved in this highly specific and tightly regulated protective-reaction mechanism are the gene products of the major histocompatibility complex (MHC) (Klein, 1975; Snell et al., 1976; Paul and Benacerraf, 1977; Götze, 1977; Snell, 1978). This genetic system was referred to as the H-2 locus when it was initially recognized as a determinant of transplantation acceptance or rejection nearly 45 years ago by P.A. Gorer (1936). The serological and genetic features were gradually unraveled over the ensuing years. The complexity, both in terms of number of genes and in terms of polymorphism, led to the use of the term H-2 major histocompatibility complex to refer to this chromosomal region in the mouse. Similar MHC complexes have been found in other species (Götze, 1977).


Major Histocompatibility Complex Tryptic Peptide Carbohydrate Moiety Cyanogen Bromide Partial Amino Acid Sequence 


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Stanley G. Nathenson
    • 1
  • Bruce M. Ewenstein
    • 1
  • Hiroshi Uehara
    • 1
  • John M. Martinko
    • 1
  • John E. Coligan
    • 2
  • Thomas J. Kindt
    • 2
  1. 1.Department of Microbiology and Immunology and Department of Cell BiologyAlbert Einstein College of MedicineBronxUSA
  2. 2.Laboratory of ImmunogeneticsNational Institutes of HealthBethesdaUSA

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