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Ia Antigens

Molecular Components in Immune Regulation?
  • Susan E. Cullen
  • Stephen M. Rose
  • Cathy S. Kindle

Abstract

Ia alloantigens are surface glycoproteins found on lymphocytes and macrophages and probably some other cell types (Shreffler and David, 1975; Hammerling et al., 1975; Cowing et al., 1978). They are antigenically quite variable, and their structure is encoded in genes mapping in the I (immune-response) region of the murine major histocompatibility complex (MHC). They are detected with the aid of alloantisera, and each molecule is antigenically complex, bearing several different antigenic determinants (Cullen et al., 1976). There are two groups of Ia molecules that are readily detected on homozygous lymphocytes, and these are currently called I-A and I-E molecules (Cullen et al., 1974, 1979; B.D. Schwartz and Cullen, 1978; Cook et al., 1978). These names are derived from the genetic subregion of origin of these molecules, but as will be seen in Section 4, it is not strictly true that the I-E molecule is derived only from the I-E subregion.

Keywords

Immune Regulation Antigenic Determinant Mixed Lymphocyte Reaction Staphylococcal Nuclease Recombinant Haplotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Benacerraf, B., and Dorf, M.E., 1976, Genetic control of specific immune responses and immune suppressions by I-region genes, Cold Spring Harbor Symp. Quant. Biol. 41:465.CrossRefGoogle Scholar
  2. Berzofsky, J., Schechter, A.N., Shearer, G.M., and Sachs, D.H., 1977a, Genetic control of the immune response to Staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments, J. Exp. Med. 145:111.CrossRefGoogle Scholar
  3. Berzofsky, J., Schechter, A.N., Shearer, G.M., and Sachs, D.H., 1977b, Genetic control of the immune response to Staphylococcal nuclease. IV. H-2 linked control of the relative proportions of antibodies produced to different determinants of native nuclease, J. Exp. Med. 145:123.CrossRefGoogle Scholar
  4. Brown, J.L., Kato, K., Silver, J., and Nathenson, S.G., 1974, Notable diversity in peptide composition of murine H-2K and H-2D alloantigens, Biochemistry 13:3174.PubMedCrossRefGoogle Scholar
  5. Cook, R.G., Uhr, J.W., Capra, J.D., and Vitetta, E.S., 1978, Structural studies on the murine Ia alloantigens. II. Molecular weight characterization of the I-A and I-E/C subregions, J. Immunol. 121:2205.PubMedGoogle Scholar
  6. Cook, R.G., Vitetta, E.S., Uhr, J.W., and Capra, J.D., 1979, Structural studies on murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion, J. Exp. Med. 149:981.PubMedCrossRefGoogle Scholar
  7. Cowing, C., Schwartz, B.D., and Dickler, H.B., 1978, Macrophage Ia antigens. I. Macrophage populations differ in their expression of Ia antigens, J. Immunol. 120:378.PubMedGoogle Scholar
  8. Cullen, S.E., and Nathenson, S.G., 1974, Further characterization of Ia (immune response region associated antigen molecules), in: The Immune System: Genes, Receptors, Signals (E.E. Sercarz, A.R. Williamson, and C.F. Fox, eds.), p. 191, Academic Press, New York.Google Scholar
  9. Cullen, S.E., and Schwartz, B.D., 1976, An improved method for isolation of H-2 and Ia alloantigens using immune precipitation induced by protein A-bearing Staphylococci, J. Immunol. 117:136.PubMedGoogle Scholar
  10. Cullen, S.E., David, C.S., Shreffler, D.C., and Nathenson, S.G., 1974, Membrane molecules determined by the H-2 associated immune response region: Isolation and some properties, Proc. Natl. Acad. Sci. U.S.A. 71:648.PubMedCrossRefGoogle Scholar
  11. Cullen, S.E., David, C.S., Cone, J.L., and Sachs, D.H., 1976, Evidence for more than one Ia antigenic specificity on molecules determined by the I-A subregion of the mouse major histocompatibility complex, J. Immunol. 116:549.PubMedGoogle Scholar
  12. Cullen, S.E., Kindle, C.S., and Littman, D.R., 1979, Structural comparison of murine Ia antigens determined by the I-A and I-E subregions, J. Immunol. 122:855.PubMedGoogle Scholar
  13. Dancey, G.F., Cutler, J., and Schwartz, B.D., 1979, Chemical cross-linking of Ia alloantigen a and β chains with dimethyl 3′, 3′-dithiobispropionimidate, J. Immunol. 123:870.PubMedGoogle Scholar
  14. Dorf, M.E., and Benacerraf, B., 1975, Complementation of H-2 linked Ir genes in the mouse, Proc. Natl. Acad. Sci. U.S.A. 72:3671.PubMedCrossRefGoogle Scholar
  15. Dorf, M.E., Stimpfling, J.H., and Benacerraf, B., 1975, Requirement for two H-2 complex Ir genes for the immune response to the L-glu, L-lys, L-phe terpolymer, J. Exp. Med. 141:1459.Google Scholar
  16. Dorf, M.E., Maurer, P.H., Merryman, C.F., and Benacerraf, B., 1976a, Inclusion group systems and cis-trans effects in response controlled by the two complementing Ir-GL∅ genes, J. Exp. Med. 143:889.PubMedCrossRefGoogle Scholar
  17. Dorf, M.E., Twigg, M.B., and Benacerraf, B., 1976b, Genetic control of the immune response to the random linear terpolymer of L-glutamic acid, L-lysine and L-leucine (GL leu) by complementing Ir genes, Eur. J. Immunol. 6:552.PubMedCrossRefGoogle Scholar
  18. Fathman, C.G., and Nabholz, M., 1977, In vitro secondary mixed lymphocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells, Eur. J. Immunol. 7:370.PubMedCrossRefGoogle Scholar
  19. Fathman, C.G., Watanabe, T., and Augustin, A., 1978, In vitro secondary MLR. III. Hybrid histocompatibility determinants, J. Immunol. 121:259.PubMedGoogle Scholar
  20. Freed, J.H., and Nathenson, S.G., 1977, Similarity of the carbohydrate structures of H-2 and Ia glycoproteins, J. Immunol. 119:477.PubMedGoogle Scholar
  21. Frelinger, J.A., Niederhuber, J.E., and Shreffler, D.C., 1976. Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on Con A reactive cells to the I-J subregion of the H-2 complex, J. Exp. Med. 144:1141.PubMedCrossRefGoogle Scholar
  22. Hammerling, G.J., Mauve, G., Goldberg, E., and McDevitt, H.O., 1975, Tissue distribution of Ia antigens: Ia on spermatozoa, macrophages, and epidermal cells, Immunogenetics 1:428.CrossRefGoogle Scholar
  23. Hancock, W.S., Bishop, C.A., Prestidge, R.L., and Hearn, M.T.W., 1978, The use of high pressure liquid chromatography (HPLC) for peptide mapping of proteins, Anal. Biochem. 88:203.CrossRefGoogle Scholar
  24. Jones, P.P., Murphy, D.B., and McDevitt, H.O., 1978, Two-gene control of the expression of a murine Ia antigen, J. Exp. Med. 148:925.PubMedCrossRefGoogle Scholar
  25. Kapp, J.A., Pierce, C.W., Schlossman, S., and Benacerraf, B., 1974, Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in non-responder mice by the terpolymer L-glutamic acid 60-L-alanine30-L-tyrosine10 (GAT), J. Exp. Med. 140:648.PubMedCrossRefGoogle Scholar
  26. Kipp, D.E., Sercarz, E.E., and Miller, A., 1975, Multigenic, H-2 linked control of the mouse immune response to human lysozyme (HUL), Fed. Proc. Fed. Am. Soc. Exp. Biol. 35:825 (abstract).Google Scholar
  27. Lafuse, W., Neely, B., McKean, D., and David, C., 1979, Biochemical studies of Ia gene products with xenoantisera, Fed. Proc. Fed. Am. Soc. Exp. Biol. 38:1423 (abstract).Google Scholar
  28. Melchers, I., and Rajewsky, K., 1975, Specific control of responsiveness by two complementing Ir loci in the H-2 complex, Eur. J. Immunol. 5:753.PubMedCrossRefGoogle Scholar
  29. Melchers, I., Rajewsky, K., and Shreffler, D.C., 1973. Ir-LDH B: Map position and functional analysis, Eur. J. Immunol. 3:754.PubMedCrossRefGoogle Scholar
  30. Meo, T., David, C.S., Rijnbeek, A.M., Nabholz, M., Miggiano, V., and Shreffler, D.C., 1973, Inhibition of mouse MLR by anti-Ia antisera, Transplant. Proc. 7:127.Google Scholar
  31. Merryman, C.F., Maurer, P.H., and Stimpfling, J.H., 1975, Unigenic and multigenic I region control of the immune responses of mice to the GAT10 and GL∅-GLT terpolymers, Immunogenetics 2:441.CrossRefGoogle Scholar
  32. Michaelson, J., Flaherty, L., Vitetta, E., and Poulik, M.D., 1977, Molecular similarities between the Qa-2 alloantigen and other gene products of the 17 th chromosome of the mouse, J. Exp. Med. 145:1066.PubMedCrossRefGoogle Scholar
  33. Mozes, E., Schwartz, M., and Sela, M., 1974, Antibody response of inbred mouse strains to ordered tetrapeptides of tyrosine and glutamic acid attached to multichain polyalanine or polyproline, J. Exp. Med. 140:349.PubMedCrossRefGoogle Scholar
  34. Muramatsu, T., Nathanson, S.G., Boyse, E.A., and Old, L.J., 1973, Some biochemical properties of thymus leukemia antigens solubilized from cell membranes by papain digestion, J. Exp. Med. 137:1256.PubMedCrossRefGoogle Scholar
  35. Murphy, D.B., Herzenberg, L.A., Okumura, K., Herzenberg, L.A., and McDevitt, H.O., 1976, A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes, J. Exp. Med. 144:699.PubMedCrossRefGoogle Scholar
  36. O’Farrell, P.H., 1975, High resolution two-dimensional electrophoresis of proteins, J. Biol. Chem. 250:4007.PubMedGoogle Scholar
  37. Okuda, K., and David, C.S., 1978, A new lymphocyte activating determinant locus expressed on T cells, and mapping in the I-C subregion, J. Exp. Med. 147:1028.PubMedCrossRefGoogle Scholar
  38. Okuda, K., David, C.S., and Shreffler, D.C., 1977, The role of gene products of the I-J subregion in mixed lymphocyte reactions, J. Exp. Med. 146:1561.PubMedCrossRefGoogle Scholar
  39. Okumura, K., Herzenberg, L.A., Murphy, D.B., McDevitt, H.O., and Herzenberg, L.A., 1976, Selective expression of H-2 (I region) loci controlling determinants on helper and suppressor T lymphocytes, J. Exp. Med. 144:685.PubMedCrossRefGoogle Scholar
  40. Rich, S.S., and Rich, R.R., 1976. Regulatory mechanisms in cell mediated immune responses. III. I region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions, J. Exp. Med. 143:672.PubMedCrossRefGoogle Scholar
  41. Schwartz, B.D., and Cullen, S.E., 1978, Chemical characteristics of Ia antigens, Semin. Immunopathol. 1:85.Google Scholar
  42. Schwartz, B.D., Vitetta, E.S., and Cullen, S.E., 1978, Labeling characteristics and separation of Ia antigen subunits, J. Immunol. 120:671.PubMedGoogle Scholar
  43. Schwartz, R.H., Solinger, A.M., Ultee, M., and Margoliash, E., 1978a, Genetic control of the T-lymphocyte proliferative response to cytochrome c, in: Immunobiology of proteins and peptides, I (M.Z. Atassi and A.B. Stavitsky, eds.), Adv. Exp. Med. Biol. 98:371.CrossRefGoogle Scholar
  44. Schwartz, R.H., Berzofsky, J.A., Horton, C.L., Schechter, A.N., and Sachs, D.H., 1978b, Genetic control of the T-lymphocyte proliferative response to staphylococcal nuclease: Evidence for multiple MHC-linked Ir gene control, J. Immunol. 120:1741.Google Scholar
  45. Seaver, S.S., Brown, A., Hammerling, G., and McDevitt, H.O., 1976, Genetic control of the immune response: Ability of antigens of defined amino acid sequence to be recognized by the Ir-1 gene system, Eur. J. Immunol. 6:502.PubMedCrossRefGoogle Scholar
  46. Shreffler, D.C., and David, C.S., 1975, The H-2 major histocompatibility complex and the I immune response region: Genetic variation, function, and organization, Adv. Immunol. 20:125.PubMedCrossRefGoogle Scholar
  47. Shreffler, D.C., David, C.S., Passmore, H.C., and Klein, J., 1971, Genetic organization and evolution of the mouse H-2 region: A duplication model, Transplant. Proc. 3:176.PubMedGoogle Scholar
  48. Snell, G.D., Cherry, M., and Demant, P., 1971, Evidence that H-2 private specificities can be arranged in two mutually exclusive systems possibly homologous with two subsystems of HLA, Transplant. Proc. 3:183.PubMedGoogle Scholar
  49. Stimpfling, J.H., and Durham, T., 1972, Genetic control by the H-2 gene complex of the alloantibody response to to H-2 antigen, J. Immunol. 108:947.PubMedGoogle Scholar
  50. Tada, T., Taniguchi, M., and David, C.S., 1976, Properties of the antigen-specific suppressive T cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T cell factor in the H-2 histocompatibility complex, J. Exp. Med. 144:713.PubMedCrossRefGoogle Scholar
  51. Vitetta, E.S., Uhr, J.W., and Boyse, E.A., 1972, Isolation and characterization of H-2 and TL alloantigens from the surface of mouse thymocytes, Cell. Immunol. 4:187.PubMedCrossRefGoogle Scholar
  52. Vitetta, E.S., Artzt, K., Bennett, D., Boyse, E.A., and Jacob, F., 1975, Structural similarities between a product of the T/t locus isolated from sperm and teratoma cells, and H-2 antigens isolated from splenocytes, Proc. Natl. Acad. Sci. U.S.A. 73:3215.CrossRefGoogle Scholar
  53. Zaleski, M., and Klein, J., 1974, Immune response of mice to Thy-1.1 antigen: Genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex, J. Immunol. 113:1170.PubMedGoogle Scholar
  54. Zaleski, M.B., and Klein, J., 1976, Immune response of mice to the Thy-1.1 antigen: Intra-H-2 mapping of the complemeentary Ir-Thy-1 loci, J. Immunol. 117:814.PubMedGoogle Scholar
  55. Zaleski, M., and Milgrom, F., 1973, Complementary genes controlling immune response to θ-AKR antigen in mice, J. Immunol. 110:1238.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Susan E. Cullen
    • 1
  • Stephen M. Rose
    • 1
  • Cathy S. Kindle
    • 1
  1. 1.Department of Microbiology and ImmunologyWashington University School of MedicineSt. LouisUSA

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