Structural Studies of the Murine Ia Alloantigens
The I region of the murine major histocompatibility complex (MHC) regulates a variety of immune functions through the control of cellular interactions and antigen responsiveness (Benacerraf and McDevitt, 1972; reviewed in Klein, 1975; Shreffler and David, 1975; Katz, 1977). The gene products thus far demonstrated for the I locus are cell-surface glycoproteins, designated as the Ia (immune-associated) antigens (Shreffler et al., 1974). Numerous studies have demonstrated that anti-Ia alloantisera inhibit many I-region-controlled immune responses. These include the induction of both T-lymphocyte proliferation (R.H. Schwartz et al., 1976a, 1978a) and antibody synthesis (J.A. Frelinger et al., 1975; Niederhuber and Frelinger, 1976) by certain antigens, successful collaboration among immunocompetent cells (Katz et al., 1974; Pierce et al., 1976; Kappler and Marrack, 1976), immune suppression (Murphy et al., 1976; Tada et al., 1976; Pierres et al., 1978), and the induction of mixed-lymphocyte reactions (MLR) (Meo et al., 1975). Thus, the Ia antigens may function as recognition units that mediate interactions among cells and/or between cells and antigen.
KeywordsTryptic Peptide Apparent Molecular Weight Peptide Mapping Partial Amino Acid Sequence Allelic Product
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