The Polymorphism of I-Region-Encoded Antigens among Wild Mice
Genes in the major histocompatibility complex (MHC) have been shown to control the expression of several cell-surface antigens that are involved in the differentiation and activation of cells of the immune system. These antigens can be divided into two classes on the basis of functional and structural criteria (Klein, 1977). The class I antigens are the targets of the transplantation reaction, are involved in the recognition of virus-infected cells, have a molecular weight of about 44,000 daltons, and are nonconva-lently associated with β2-microglobulin. The class II antigens are involved in the regulation of the antibody response to soluble antigens and mediate many of the interactions of immunocompetent cells. Those class II antigens that have been structurally characterized consist of two polypeptide chains and are not associated with β2-microglobulin.
KeywordsInbred Line Wild Mouse Partial Amino Acid Sequence Wild Male Typing Reagent
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- Cecka, M., McMillan, M., Murphy, D., Silver, J., McDevitt, H., and Hood, L., 1978, Partial amino acid sequence analyses of Ia antigens, in: Ir Genes and Ia Antigens (H.O. McDevitt, ed.), pp. 275–286, Academic Press, New York and London.Google Scholar
- Freed, J.H., 1978, Comparison of primary structures of Ia products from the I-A and I-E/C subregion, J. Immunol. 121:1609.Google Scholar
- Klein, J., 1973, Polymorphism of the H-2 loci in wild mice, in International Symposium on Standardization of HL-A Reagents (R.H. Regamey and J.V. Sparck, eds.), pp. 251–256, S. Karger, Basal.Google Scholar
- McMillan, M., Cecka, J.M., Frelinger, J.G., Murphy, D., Frelinger, J.A., McDevitt, H.O., and Hood, L., 1978b, Chemical characterization of murine Ia antigens, J. Immunol. 121:1608.Google Scholar
- Silver, J., and Hood, L., 1976, Preliminary amino acid sequences of transplantation antigens: Genetic and evolutionary implications, in: Contemporary Topics in Molecular Immunology (H.M. Eisen and R.A. Reisfeld, eds.), pp. 221–229, Plenum Press, New York.Google Scholar
- Silver, J., Cecka, J.M., McMillan, M., and Hood, L., 1976, Chemical characterization of products of the H-2 complex, XLI, Cold Spring Harbor Symp. Quant. Biol. 41:477.Google Scholar