The Polymorphism of I-Region-Encoded Antigens among Wild Mice

  • Edward K. Wakeland
  • Jan Klein


Genes in the major histocompatibility complex (MHC) have been shown to control the expression of several cell-surface antigens that are involved in the differentiation and activation of cells of the immune system. These antigens can be divided into two classes on the basis of functional and structural criteria (Klein, 1977). The class I antigens are the targets of the transplantation reaction, are involved in the recognition of virus-infected cells, have a molecular weight of about 44,000 daltons, and are nonconva-lently associated with β2-microglobulin. The class II antigens are involved in the regulation of the antibody response to soluble antigens and mediate many of the interactions of immunocompetent cells. Those class II antigens that have been structurally characterized consist of two polypeptide chains and are not associated with β2-microglobulin.


Inbred Line Wild Mouse Partial Amino Acid Sequence Wild Male Typing Reagent 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Edward K. Wakeland
    • 1
  • Jan Klein
    • 1
  1. 1.Department of ImmunogeneticsMax-Planck-Institute for BiologyTübingenWest Germany

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