Carbohydrate-Defined Antigens Controlled by the I Region

  • C. R. Parish
  • I. F. C. McKenzie


The I-region-associated (Ia) antigens of the mouse represent a highly polymorphic system of antigens that are coded for by a cluster of genes located within the H-2 complex (Shreffler and David, 1975; C.S. David, 1976). The possibility that these Ia antigens actually represent the product of immune-response (Ir) genes is still an unresolved issue. However, the Ia antigens undoubtedly play a role in mixed-lymphocyte reactions (MLRs) (R.H. Schwartz et al., 1976a; Okuda et al., 1977; Okuda and David, 1978) and T cell-macrophage interactions (R.H. Schwartz et al., 1976b, 1978). They are also associated with several immunoregulatory molecules, such as helper factors (Armerding et al., 1974; Munro and Taussig, 1975; Howie and Feldmann, 1977) and suppressor factors (Tada et al., 1976; Théze et al., 1977) of antibody formation and suppressor factors of contact sensitivity (Greene et al., 1977) and MLRs (Rich et al., 1977).


Spleen Cell Migration Inhibition Factor Mouse Serum Rabbit Antiserum Carbonyl Iron 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • C. R. Parish
    • 1
  • I. F. C. McKenzie
    • 2
  1. 1.Department of Microbiology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia
  2. 2.Department of MedicineAustin HospitalHeidelbergAustralia

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