Induction of γ-Glutamyl Transpeptidase in Isolated Cerebral Endothelial Cells
Interest in the possible role of gamma-glutamyl transpeptidase (γ-GTP)* in the differentiated function of blood-brain barrier endothelium comes from the implication of the enzyme in amino acid transport because of the association of high levels of this enzyme with areas of high rates of amino acid transport. Several lines of evidence support this concept (1–4), including the demonstration that γ-GTP can function as an integral part of the γ-glutamyl cycle (5,6) and that the γ-glutamyl cycle participates in amino acid transport (7). Of particular relevance to this report is the work of Orlowski et al (2), suggesting that γ-GTP may play a role in the transfer of at least some amino acids across the blood-brain barrier.
KeywordsAmino Acid Transport Cerebral Microvessels Inductive Force Fetal Bovine Seron Epithelial Brush Border
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