Transport of Sodium and Potassium across the Blood-Brain Barrier

  • H. M. Eisenberg
  • R. L. Suddith
  • J. S. Crawford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)


Active transport of sodium and potassium across the blood-brain barrier (BBB) has been suspected, but until quite recently, there has been no direct evidence that the blood vessels of the central nervous system (CNS) are even capable of this kind of transport. Evidence from in vivo experiments indicated that special mechanisms at the blood-brain barrier regulated the concentration of potassium in the brain extracellular fluid (ECF) (1). Interpretation of these experiments, however, is complicated by the difficulty in assigning specific transport properties to the walls of the blood vessels when the effects of choroid plexus and glia cannot be excluded (2).


ATPase Activity Choroid Plexus Cerebral Spinal Fluid Cerebral Microvessels Cation Uptake 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • H. M. Eisenberg
    • 1
  • R. L. Suddith
    • 1
  • J. S. Crawford
    • 1
  1. 1.Division of Neurosurgery, Department of SurgeryThe University of Texas Medical BranchGalvestonUSA

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