Transport of Sodium and Potassium across the Blood-Brain Barrier
Active transport of sodium and potassium across the blood-brain barrier (BBB) has been suspected, but until quite recently, there has been no direct evidence that the blood vessels of the central nervous system (CNS) are even capable of this kind of transport. Evidence from in vivo experiments indicated that special mechanisms at the blood-brain barrier regulated the concentration of potassium in the brain extracellular fluid (ECF) (1). Interpretation of these experiments, however, is complicated by the difficulty in assigning specific transport properties to the walls of the blood vessels when the effects of choroid plexus and glia cannot be excluded (2).
KeywordsATPase Activity Choroid Plexus Cerebral Spinal Fluid Cerebral Microvessels Cation Uptake
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