Changes in Blood-Brain Transfer Parameters Induced by Hyperosmolar Intracarotid Infusion and by Metastatic Tumor Growth
The transport of solutes and water between blood and brain tissue depends on such things as the rate of tissue blood flow, the permeabilities of the capillary and cellular membranes, and the sizes of the various tissue distribution spaces. In some pathologic situations, the primary cause of the lesion is the interruption of the normal operation of one or more of these transport components, for example, local tissue blood flow in stroke. In other conditions, the presence of the initial pathologic disturbance subsequently affects the movements of materials within the system, for instance, the development of edema in and around a tumor site.
KeywordsMetastatic Brain Tumor Tissue Blood Flow Transfer Constant Amino Isobutyric Acid Intracarotid Infusion
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- 5.Sakurada O, Kennedy C, Jehle J, et als Measurement of local cerebral blood flow with iodo [14C] antipyrine. Am J Physiol 3, SH59–H66, 1978.Google Scholar
- 6.Goochee C, Rasband W, Sokoloff Ls Computerized densitometry and color coding of [14C] deoxyglucose autoradiographs. Ann Neurol, in press.Google Scholar
- 8.Kety SS Measurements of local blood flow by the exchange of an inert, diffusible substance. Methods Med Res 8, 228–236, 1960.Google Scholar
- 10.Ohno K, Pettigrew K, Rapoport Ss Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 235SH299–H307, 1978.Google Scholar
- 11.Gazendam J, Blasberg RG, Patlak CS. An autoradiographic study of capillary permeability during hyper-osmotic opening. Proceedings of the Fourth International Symposium on Intracranial Pressure, New York, Springer-Verlag, in press.Google Scholar