Behaviour of the Blood-Brain Barrier Toward Biogenic Amines in Experimental Cerebral Ischemia
Considering the blood-brain barrier (BBB) as a conglomerate of regulatory systems concerned with maintenance of a homeostatically controlled biochemical environment for the brain parenchyma, it can be assumed that any dysfunction of these systems caused by cerebral ischemia may significantly influence the pathology of resulting lesions. Previous studies of the effect of ischemia on the BBB demonstrated that various substances differ with regard to the time and intensity of their abnormal passage from blood into brain. Thus, it was demonstrated that after cerebral ischemia, the breakdown of the BBB to micromolecular substances such as 14C-sucrose or sodium fluorescein precedes and lasts much longer than the breakdown of the BBB to proteins (1), which occurs with a delay dependent upon the severity of ischemic insult, according to the principle of the “maturation” phenomenon (2,3).
KeywordsCerebral Ischemia Biogenic Amine Evans Blue Mongolian Gerbil Sodium Fluorescein
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