The Effect of Severe Hypoxia on Cerebral Glucose Flux
We have already studied the changes that result in altered glucose transport and metabolism when the isolated canine brain is perfused with blood having a normal glucose concentration, but an arterial PO2 of less than 10 mmHg (1,2). After the first minute following initiation of anoxic perfusion, the rate of glucose utilization increases and, at normal arterial glucose concentrations, actually exceeds the capacity for glucose to be transported across the blood-brain barrier (BBB). The result is that the whole brain glucose concentration rapidly falls to less than 24% of normal after 10 minutes of anoxic perfusion and to nearly zero after a total of 30 minutes of anoxic perfusion (3).
KeywordsGlucose Concentration Glucose Transport Capillary Endothelial Cell Brain Glucose Glucose Flux
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