Alterations in Cerebral Blood Flow Immediately after Brief Periods of Stasis

  • E. G. Fischer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)


In the 1960s, Ames and his coworkers (1–4), described an obstructive process in cerebral microvessels that followed periods of experimental stasis as short as 7 minutes. Called no-reflow, the phenomenon was of interest because it appeared within the time frame of the development of an irreversible ischemic brain injury. Subsequent study has led to the belief that the obstruction is caused mainly by sludging of erythrocytes and can be overcome by a blood pressure pulse of approximately 100 mmHg in the immediate postischemic period. Once flow is restarted, autoregulation, however, is lost so that the passive dependence of flow on pressure results in postischemic cerebral blood flows of more than twice preischemic levels when blood pressure is restored to the preischemic value (5).


Circulatory Arrest Infusion Pressure Carbon Infusion Cerebral Microvessels Blood Pressure Pulse 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • E. G. Fischer
    • 1
    • 2
  1. 1.Department of Neurosurgery, Children’s Hospital Medical CenterHarvard Medical SchoolBostonUSA
  2. 2.Department of SurgeryHarvard Medical SchoolBostonUSA

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