Alterations in Cerebral Blood Flow Immediately after Brief Periods of Stasis
In the 1960s, Ames and his coworkers (1–4), described an obstructive process in cerebral microvessels that followed periods of experimental stasis as short as 7 minutes. Called no-reflow, the phenomenon was of interest because it appeared within the time frame of the development of an irreversible ischemic brain injury. Subsequent study has led to the belief that the obstruction is caused mainly by sludging of erythrocytes and can be overcome by a blood pressure pulse of approximately 100 mmHg in the immediate postischemic period. Once flow is restarted, autoregulation, however, is lost so that the passive dependence of flow on pressure results in postischemic cerebral blood flows of more than twice preischemic levels when blood pressure is restored to the preischemic value (5).
KeywordsCirculatory Arrest Infusion Pressure Carbon Infusion Cerebral Microvessels Blood Pressure Pulse
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- 7.Harrison MJG, Sedal L, Arnold J, et al: No-reflow phenomenon in the cerebral circulation of the gerbil. J Neurol Neurosurg, Psychiat 38: 1190–1193, 1975.Google Scholar
- 10.Diethelon AG: Effect of ischemia upon renal microcirculation: Preliminary observations. Am Surg 35: 833–835, 1969.Google Scholar
- 14.Strock PE, Majno G: Microvascular changes in acutely ischemic rat muscle. Surg Gynecol Obstet 129:1213- 1224, 1969.Google Scholar
- 18.Merrill EW, Meiselman HJ, Gilliland ER, et al: Flow of human blood in glass and plastic fibers: A filmed study. In, Wolstenholme GEW and Knight J (eds): DIBA Foundation Symposium on Circulatory and Respiratory Mass Transport, London, J & A Churchill, 1969, pp 130–131.Google Scholar
- 19.Merrill EW: Rheology of blood. Physiol Rev 49: 863–888, 1969.Google Scholar