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Changes in the Cerebral Vasculature after Hypertension and Trauma: A Combined Scanning and Transmission Electron Microscopic Analysis

  • J. T. Povlishock
  • H. A. Kontos
  • E. P. Wei
  • W. I. Rosenblum
  • D. P. Becker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

In recent studies we evaluated the effect of low intensity mechanical brain injury on the neuraxis. Through such studies we ascertained that brain injuries of sufficient intensity to elicit a concussive response, yet of insufficient intensity to cause light microscopic change, caused both transient opening of the brain stem blood-brain barrier to horseradish peroxidase (HRP) (1,2) and local neuronal inundation with this protein tracer (3). As these neuronal and vascular changes were both subtle and transient, they appeared consistent with the mild and transitory nature of the concussive event. Therefore, it was thought that these events were morphologic correlates of the concussive episode (3). Although our hypothesis appears credible, several factors previously not evaluated may have played a role in the genesis of the observed lesions. Most significantly, the concussive injury was commonly accompanied by a hypertensive episode, which in itself may have been responsible for the observed changes. Thus, we questioned if the changes we observed were secondary to post-traumatic hypertension.

Keywords

Basal Lamina Hypertensive Episode Cerebral Endothelium Concussive Injury Altered Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. T. Povlishock
    • 1
    • 2
    • 3
    • 4
  • H. A. Kontos
    • 1
    • 2
    • 3
    • 4
  • E. P. Wei
    • 1
    • 2
    • 3
    • 4
  • W. I. Rosenblum
    • 1
    • 2
    • 3
    • 4
  • D. P. Becker
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of AnatomyMedical College of Virginia, Health Sciences Division of Virginia Commonwealth UniversityRichmondUSA
  2. 2.Department of MedicineMedical College of Virginia, Health Sciences Division of Virginia Commonwealth UniversityRichmondUSA
  3. 3.Department of PathologyMedical College of Virginia, Health Sciences Division of Virginia Commonwealth UniversityRichmondUSA
  4. 4.Department of SurgeryMedical College of Virginia, Health Sciences Division of Virginia Commonwealth UniversityRichmondUSA

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