Factors which Determine Cerebrovascular Permeability in the Normal Brain and Following Osmotic Treatment

  • S. I. Rapoport
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)


The endothelial cell layer of the cerebral vasculature as a whole has properties of an extended lipoid cell membrane, and is permselective for lipid-soluble as compared to water-soluble substances (1,2). This selective permeability of the barrier to lipid-soluble drugs qualitatively explains different rates of drug passage from plasma to spinal fluid and brain, and may account for observed correlations between therapeutic effectiveness of centrally-acting drugs and lipid solubility (3). For example, the central effectiveness of a series of barbiturates, hydantoins and imides increases with lipid solubility (2,4,5).


Partition Coefficient Brain Uptake Lipid Solubility Osmotic Treatment Cerebral Capillary 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • S. I. Rapoport
    • 1
  1. 1.Laboratory of Neurosciences, National Institute on Aging Gerontology Research CenterBaltimore City HospitalsBaltimoreUSA

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