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Factors which Determine Cerebrovascular Permeability in the Normal Brain and Following Osmotic Treatment

  • S. I. Rapoport
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

The endothelial cell layer of the cerebral vasculature as a whole has properties of an extended lipoid cell membrane, and is permselective for lipid-soluble as compared to water-soluble substances (1,2). This selective permeability of the barrier to lipid-soluble drugs qualitatively explains different rates of drug passage from plasma to spinal fluid and brain, and may account for observed correlations between therapeutic effectiveness of centrally-acting drugs and lipid solubility (3). For example, the central effectiveness of a series of barbiturates, hydantoins and imides increases with lipid solubility (2,4,5).

Keywords

Partition Coefficient Brain Uptake Lipid Solubility Osmotic Treatment Cerebral Capillary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • S. I. Rapoport
    • 1
  1. 1.Laboratory of Neurosciences, National Institute on Aging Gerontology Research CenterBaltimore City HospitalsBaltimoreUSA

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