Blood-Brain Barrier Transport During Anesthesia

  • E. M. Nemoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)


The effects of anesthetics on the central nervous system can be described in terms of their primary direct action on membranes and enzymes or their secondary effects on brain function and metabolism. Elucidation of some of the direct effects of anesthetics on membranes such as lateral phase separation (1), membrane expansion (2,3) and membrane lipoprotein conformational changes (4) strongly suggest that alterations in membrane transport processes are likely to occur. The aim of the studies to be described was to elucidate the effects of anesthetics on blood-brain barrier (BBB) glucose transport. Changes in glucose transport may result from both the primary and secondary effects of anesthetics.


Glucose Transport Halothane Anesthesia Inhalation Anesthetic Cerebral Metabolic Rate Anesthetic Group 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • E. M. Nemoto
    • 1
  1. 1.The Anesthesia and Critical Care Research Laboratories Department of Anesthesiology and Critical Care MedicineUniversity of Pittsburgh School of MedicinePittsburghUSA

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