Blood-Brain Barrier Transport During Anesthesia
The effects of anesthetics on the central nervous system can be described in terms of their primary direct action on membranes and enzymes or their secondary effects on brain function and metabolism. Elucidation of some of the direct effects of anesthetics on membranes such as lateral phase separation (1), membrane expansion (2,3) and membrane lipoprotein conformational changes (4) strongly suggest that alterations in membrane transport processes are likely to occur. The aim of the studies to be described was to elucidate the effects of anesthetics on blood-brain barrier (BBB) glucose transport. Changes in glucose transport may result from both the primary and secondary effects of anesthetics.
KeywordsGlucose Transport Halothane Anesthesia Inhalation Anesthetic Cerebral Metabolic Rate Anesthetic Group
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