Immobilized Penicillin Acylase for Production of 6-Apa From Penicillin-V

  • Stina Gestrelius


6-APA (6-aminopenicillanic acid) is the well-known β-lactam nucleus needed for production of semisynthetic penicillins. It is produced from natural penicillins, such as penicillin-G and penicillin-V, either chemically or enzymatically.


Ethylene Imine Fermentation Extract Semisynthetic Penicillin Acylase Activity Increase Buffer Capacity 


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  1. 1.
    BRANDT, E., KLEIBER, W. & KNAUSEDER, F. Austrian patent 11148, 1969.Google Scholar
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    BIERS, I. & Emborg, C. to be published.Google Scholar
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    BALASINGHAM, K., WARBURTON, D., DUNNILL, P. & LILLY, M.D. Biochim. Biophys. Acta 276; 250, 1972.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Stina Gestrelius
    • 1
  1. 1.Novo Research InstituteBagsvaerdDenmark

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