Continuous Deacetylation of Cephalosporins

  • Jan Konecny
  • Meinrad Sieber


The non-specific acetyl esterase from B. subtilis (AT 6633) has been immobilized on several carriers represeating a wide range of binding capacities, morphologies and physical and mechanical properties (1,2,3). The relative merits of batch and continuous reactors for the deacetylation of cephalosporins with the enzyme have been discussed (3).


Space Velocity Microbial Matter Free Enzyme Column Performance Column Efficiency 
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    KONECNY, J. & SLANICKA, J. Biochim. Biophys. Acta 403: 573, 1975.Google Scholar
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Jan Konecny
    • 1
  • Meinrad Sieber
    • 1
  1. 1.Pharmaceuticals DivisionCIBA-GEIGY LimitedBaselSwitzerland

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