Synthesis of Coenzymes by Immobilized Cell System
Recent developments in the utilization of coenzymes for medicine, in animal feed and as reagents for biochemical analysis have raised interest in the economical production of coenzymes and brought a number of papers on preparative methods for coenzymes. In previous papers (1–4), we revealed that such useful coenzymes as CoA, FAD and pyridoxal 5′-phosphate can conveniently and efficiently be synthesized by enzymatic processes which employ microbial cells as enzyme sources. In the present paper, we describe the immobilization of these microbial cells and the continuous synthesis of these coenzymes by the immobilized cells as stable catalysts.
KeywordsImmobilize Cell Sodium Laurylsulfate Pantothenic Acid Substrate Mixture Continuous Synthesis
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