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Immobilized Whole Cells of the Yeast Trigonopsis Variabilis Containing D-Amino Acid Oxidase For The Production of α-Keto Acids

  • P. Brodelius
  • B. Hagerdal
  • K. Mosbach

Abstract

α-Keto acids have great potential for the treatment of various diseases and more in particular the analogs of the essential amino acids for treatment of acute uremia. A more thorough investigation of this therapeutic approach has been complicated by the difficulty in preparing such keto-analogs. Chemical synthesis is often difficult and elaborate, resulting in low yields. However, many keto acids can be prepared form the corresponding amino acids by an enzymatic reaction involving amino acid oxidase. Actually, for some keto acids this is at present the only realistic method of production.

Keywords

Essential Amino Acid Manganese Oxide Acid Oxidase Keto Acid Immobilize Biocatalyst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    FINK, D.J., FALB, R.D. & BEAN, M.K. In Advances in Enzyme Engineering, Vol. 2, (G. T. Tsao, ed.) Purdue University, West Lafayette, IN, 1976, pp. 79–113.Google Scholar
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    PARKIN, K. & HULTIN, H.O. Biotech. Bioeng. 21: 939–953, 1979.CrossRefGoogle Scholar
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    BRODELIUS, P. & MOSBACH, K. Swedish Patent Application 79: 8264, 1979.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • P. Brodelius
    • 1
  • B. Hagerdal
    • 1
  • K. Mosbach
    • 1
  1. 1.Biochemistry 2, Chemical CenterUniversity of Lund/Instiute of TechnologyLundSweden

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