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Magnetic Microspheres for Targeting of Drugs

  • Klaus Mosbach
  • Ulf Schroder

Abstract

Specific delivery of drugs to desired target sites with a minimum of side effects constitutes one of the most exciting challenges in medicine. One way of achieving such targeting of drugs is the use of magnetic microspheres in combination with an external magnetic field. In general, when using magnetic particles in drug delivery, ideally the following requirements should be met:
  1. 1.

    The particles should be small enough to remain in the circulation after injection (i.e. ∅ <2–3 μm).

     
  2. 2.

    The magnetic material should be non-toxic.

     
  3. 3.

    The polymer should be biocompatible, i.e. non-toxic and non-immunogenic.

     
  4. 4.

    The polymer should allow binding of drugs by covalent attachment, adsorption or entrapment.

     

Keywords

Magnetic Material External Magnetic Field Covalent Attachment Magnetic Microsphere Specific Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    MOSBACH, K. & SCHRODER, U. FEBS Lett. 102: 112, 1979.CrossRefGoogle Scholar
  2. 2.
    SCHRODER, U., NILSSON, K. & MOSBACH, K. To be published.Google Scholar
  3. 3.
    SALFORD, L., BRUN, A., SCHRODER, U. & MOSBACH, K. To be published.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Klaus Mosbach
    • 1
  • Ulf Schroder
    • 1
  1. 1.Biochemistry 2, Chemical CenterUniversity of LundLundSweden

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