Abstract
The basic problems researchers deal with on the elaborattion of novel enzyme preparations are:
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increase of the enzyme stability in vivo realtive to the action of endogenous proteinases, inhibitors and antibodies;
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stability increase on storage;
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decrease of the organism response to foreign protein, and namely decrease of their immunogenicity, antigenicity, allergenicity potential and toxicity;
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decrease of the enzyme preparation dose;
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prolongation of the enzyme action or ensurance of the enzyme preparations pharmacokinetics.
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© 1980 Plenum Press, New York
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Chazov, E.I., Smirnov, V.N., Torchilin, V.P., Tereshin, I.M., Moskvichev, B.V. (1980). Immobilized Enzymes for Medical Application. In: Weetall, H.H., Royer, G.P. (eds) Enzyme Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3749-2_33
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DOI: https://doi.org/10.1007/978-1-4684-3749-2_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3751-5
Online ISBN: 978-1-4684-3749-2
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