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Potentiometric Enzymatic Measurement of Glucose: Possible in vivo Use

  • L. B. WingardJr.
  • S. K. WolfsonJr.
  • C. C. Liu
  • S. J. Yao
  • J. G. Schiller
  • A. L. Drash

Abstract

The development of a sensor for continuous in vivo measurement of glucose concentrations in body fluids, without the necessity for withdrawal of fluid from the body, is an important clinical and research need for improved understanding and treatment of diabetes. Several approaches for the development of such a sensor are discussed elsewhere (1). During our studies with glucose oxidase, we observed that a glucose oxidase-catalase-platinum electrode gave a direct Potentiometric response, with respect to a reference electrode, when both electrodes were placed in the same beaker of buffered glucose solutions. We have pursued these observations further to assess the applicability that this approach may have for the development of the needed in vivo glucose sensor. The purpose of this paper is to summarize our results to date.

Keywords

Glucose Concentration Cellulose Acetate Glucose Oxidase Glucose Sensor Enzyme Electrode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1..
    WINGARD, JR., L.B., SCHILLER, J.G., WOLFSON, JR., S.K., LIU, C.C., DRASH, A.L., & YAO, S.J. J. Biomed. Mat. Res. in press.Google Scholar
  2. 2..
    LIU, C.C., WINGARD, J.R, WOLFSON, JR., S.K., YAO, S.J., DRASH, A.L., & SCHILLER, J.G. Bioelectrochem. Bioengetics 6: 19, 1979.CrossRefGoogle Scholar
  3. 3..
    WINGARD, JR., L.B., ELLIS. D., YAO, S.J., SCHILLER, J.G., LIU, C.C., WOLFSON, JR., S.K., & DRASH, A.L. J. Solid-Phase Biochem. in press.Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • L. B. WingardJr.
    • 1
  • S. K. WolfsonJr.
    • 2
  • C. C. Liu
    • 3
  • S. J. Yao
    • 2
  • J. G. Schiller
    • 3
  • A. L. Drash
    • 4
  1. 1.Departments of Pharmacology, School of MedicineUniversity of PittsburghPittsburghUSA
  2. 2.Neurological Surgery, School of MedicineUniversity of PittsburghPittsburghUSA
  3. 3.Department of Chemical EngineeringUniversity of PittsburghPittsburghUSA
  4. 4.Neurological Pediatrics, School of MedicineUniversity of PittsburghPittsburghUSA

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