Rheology pp 511-517 | Cite as

Synovial Fluid Rheology, Hyaluronic Acid and Macromolecular Network Structure

  • Henning Zeidler
  • Siegfried Altmann


Former investigations 1,2,3,4,5,6 of the synovial fluid with modern rheological methods clearly showed a high reduction of the viscosity and elasticity in rheumatoroid arthritis and other arthropathies. The reduction of the concentration and the molecular weight of the hyaluronic acid (HA) is the obvious cause of pathorheological changes. For rheumatoid arthritis the dissociation of a macro-molecular complex of HA and proteins 7,8 is also taken into consideration.


Rheumatoid Arthritis Shear Rate Hyaluronic Acid Synovial Fluid Flow Curve 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R.R.Myers, S. Negami and R.K. White: Dynamic mechanical properties of synovial fluid. Biorheology 3: 197 (1966)Google Scholar
  2. 2.
    D.V. Davies and A.J. Palfrey: Some of the physical properties of normal and pathological synovial fluids. J. Bianechanics 1: 79 (1968)CrossRefGoogle Scholar
  3. 3.
    F. Ferguson, J.A. Boyle, R.N.M. McSween and M.K. Jasani: Obser- vations on the flow properties of the synovial fluid from patient with rheumatoid arthritis. Biorheology 5: 119 (1968)Google Scholar
  4. 4.
    G.B. Thursten and H. Greiling: Viscoelastic properties of pathological synovial fluids for a wide range of oscillatory shear rates and frequencies. Rheol. Acta 17: 433 (1978)CrossRefGoogle Scholar
  5. 5.
    I. Anadere, H. Chanel and W. Laschner: Viscoelasticity of normal and pathological synovial fluid. Biorheology 16: 179 (1979)Google Scholar
  6. 6.
    H. Zeidler, S. Altmann, B. John, R. Gaffga and W.-M. Kulicke: Rheologie pathologischer GelenkflUssigkeiten. 1. Weitere Ergebnisse zur Viskoelastizität. Rheol. Acta 18: 151 (1979)CrossRefGoogle Scholar
  7. 7.
    J. Ferguson, J.A. Boyle and G. Nuki: Rheological evidence for the existance of dissociated macratolecular ooanplexes in rheumatoid synovial fluid. Clin.Sci. 37: 739 (1969)Google Scholar
  8. 8.
    G. Nuki and J. Ferguson: Studies on the nature and significance of macrarolecular complexes inlhe rheology of synovial fluid from normal and diseased human joints. Rheol. Acta 10: 8 (1971)CrossRefGoogle Scholar
  9. 9.
    T. Bitter and H.M. Muir: A modified urtunlc acid carbazole reaction. Anal. Biochem. 4: 330 (1962)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Henning Zeidler
    • 1
  • Siegfried Altmann
    • 1
  1. 1.Div. of Rheumatic and Metabolic DiseasesMedical Department, MHHHannover 31Germany

Personalised recommendations