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Rheology pp 467-480 | Cite as

Molecular Rheology of Human Blood: Its Role in Health and Disease (to Day and to Morrow ?)

  • Leopold Dintenfass

Abstract

Hyperviscosity syndrome (or ‘hyperviscosaemia’), in which an elevation of one or more of the blood viscosity factors (such as viscosity of plasma, viscosity of whole blood, aggregation of red cells, rigidity/deformability of blood cells, aggregation of platelets, thrombus formation, etc.) might take place, can lead to ischaemia, infarction and necrosis of the tissue; in the case of increased aggregation of red cells it might play a role in the cancer metastasis; in the case of rigidity of red cells, it might play a role in hypertension and diabetes.

The theoretical studies of blood cells are of great interest, as the red cells represent a nearly ideal emulsion. The liquid — crystalline components of the red cell membrane and of the cell interior supply an array of catalytic and mechano-chemical opportunities.

The practical applications of rheological findings will find a place in diagnosis and therapy of heart diseases, hypertension, diabetes and cancer; and might become of particular importance in screening for the silent (not detectable by the usual means) cardiovascular diseases.

A scope opens slowly for a study of rheology of blood under conditions of near-zero gravity. This might be not only of interest to the future space-travellers, but might answer certain basic questions, an answer to which cannot be obtained under 1 gravity.

Keywords

Shear Rate Blood Viscosity High Shear Rate Plasma Viscosity Guard Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Leopold Dintenfass
    • 1
  1. 1.Haemorheology & Biorheology Department Medical Research KMI, Sydney Hospital and Department of MedicineUniversity of SydneySydneyAustralia

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