Hydrodynamic Properties of Collagen Fibril and Aging
One biochemical approach to aging research has been to isolate bodily structural components, study their physiochemical properties, and establish the molecular basis for bodily changes during the aging process. This approach has been particularly fruitful in the field of connective tissue research, ever since soluble collagen was first isolated from tendon, and synthetic fibrils were reconstituted from the soluble collagen in vitro (1). When, in addition to soluble collagens and soluble ground substances, connective tissue components with high order structures, observable as collagen fibril, collagen fiber, and collagen fiber bundle (2) are isolated and characterized, such age-related changes as shrinkage temperature and tensile strength of skin (3) may be able to be expressed in terms of the physiochemical properties of their structural components.
KeywordsCollagen Fibril Physiochemical Property Collagen Molecule Viscosity Change Specific Viscosity
Unable to display preview. Download preview PDF.
- 1.J. Nageotte, Coagulation fibrillaire in vitro du collagène dissous dans un acide dilué, Compt. Rend. Acad. Sci. 184:115 (1927).Google Scholar
- 2.A. J. Cruise, The structure and deformation of collagen fibers. II. The morphology of collagen fibers, J. Soc. Leather Chemists 40:321 (1965).Google Scholar
- 3.D. M. Rusmussen, K. G. Wakim, and R. K. Winkelmann, Effect of aging on human dermis: Studies of thermal shrinkage and tension, in: “Advances in Biology of Skin, Vol. VI, Aging,” W. Montagna, ed., Pergamon Press, Oxford (1964).Google Scholar
- 5.W. Schwarz, Morphology and differentiation of the connective tissue fibres, in: “Connective Tissue,” R. E. Tunbridge, M. Keech, J. F. Delafresnaye, and G. C. Woods, eds., Blackwell Scientific Publications, Oxford (1957).Google Scholar
- 8.A. Miller, Molecular packing in collagen fibrils, in: “Biochemistry of Collagen,” G. N. Ramachandran and A. H. Reddi, eds., Plenum Press, New York (1976).Google Scholar
- 9.W. G. Banfield, Occurrence of tapered collagen fibrils from human sources with observations on mesenchymal neoplasms, Proc. Soc. Exp, Biol. Med. 81:658 (1952).Google Scholar
- 12.T. Matsumura, M. Hasegawa, and M. Shigei, Collagen biochemistry and phylogeny of echinoderms, Comp. Biochem. Physiol. 62B:101 (1978).Google Scholar
- 13.T. Matsumura, Shape, size and amino acid composition of collagen fibril of the starfish Asterias amurensis, Comp. Biochem. Physiol. 44B:1197 (1973).Google Scholar
- 15.K. Mitsukuri, Notes on the habits and life-history of Stichopus japonicus Selenka, Annot. Zool. Japan 5:1 (1903).Google Scholar