Mechanism of Age-Dependent Decrease in Sulfation of Chondroitin Sulfate
A number of investigators have been concerned with the relationship between extracellular substances and aging (1,2). It is generally recognized that the amount of hexosamine-containing substances in tissue decreases with age, while the insoluble collagen content in the tissue increases with age (3). Recently, it has been reported that the decrease in elasticity of cartilage with age is related to the content and structure of the proteoglycan in the matrix (4).
KeywordsChondroitin Sulfate Keratan Sulfate Costal Cartilage Chondroitin Sulfate Chain Repeat Disaccharide Unit
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- 1.H. G. Vogel, ed., “Connective Tissue and Ageing,” Excerpta Medica, Amsterdam (1973).Google Scholar
- 2.D. A. Hall, ed., “The Aging of Connective Tissue,” Academic Press, London (1976).Google Scholar
- 3.H. Boström, in: “Aging of Connective and Skeletal Tissue,” A. Engel and T. Larson, eds., Nordiska Bokhandelsforlag, Stockholm (1969).Google Scholar
- 9.H. Iwata, The determination and fine structures of chondroitin sulfate isomers of human cartilage and pathological tissues, J. Jap. Orthop. Assoc. 43:455 (1969).Google Scholar