Mechanism of Age-Dependent Decrease in Sulfation of Chondroitin Sulfate

  • Sei-itsu Murota
  • Atsushi Honda
  • Midori Abe
  • Yo Mori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


A number of investigators have been concerned with the relationship between extracellular substances and aging (1,2). It is generally recognized that the amount of hexosamine-containing substances in tissue decreases with age, while the insoluble collagen content in the tissue increases with age (3). Recently, it has been reported that the decrease in elasticity of cartilage with age is related to the content and structure of the proteoglycan in the matrix (4).


Chondroitin Sulfate Keratan Sulfate Costal Cartilage Chondroitin Sulfate Chain Repeat Disaccharide Unit 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Sei-itsu Murota
    • 1
  • Atsushi Honda
    • 1
    • 2
  • Midori Abe
    • 1
  • Yo Mori
    • 2
  1. 1.Department of PharmacologyTokyo Metropolitan Institute of GerontologyItabashi-ku, Tokyo 173Japan
  2. 2.Department of BiochemistryTokyo College of PharmacyHachioji-shi, Tokyo 192-03Japan

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