Population Doubling Numbers in Cells with Genetic Disorders

  • Osamu Nikaido
  • Sadayuki Ban
  • Tsutomu Sugahara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


The limited life spans of fibroblasts derived from human embryonic lungs were first reported by Hayflick (1). Then, the correlation between doubling potentials of cells and maximal life spans of donor animals (2) as well as the inverted correlation between doubling potentials of human fibroblasts and ages of donors were established (3). Thus, it has been thought that cells age as donors age, or cells in vitro at least mimic parts of various processes of in vivo aging, although the mechanisms of cellular aging are not yet known.


Cellular Aging Population Doubling Ataxia Telangiectasia Xeroderma Pigmentosum Ataxia Telangiectasia 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Osamu Nikaido
    • 1
  • Sadayuki Ban
    • 2
  • Tsutomu Sugahara
    • 1
  1. 1.Radiation Biology Center and Department of Experimental RadiologyKyoto UniversityKyoto 606Japan
  2. 2.Faculty of MedicineKyoto UniversityKyoto 606Japan

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