Population Doubling Numbers in Cells with Genetic Disorders
The limited life spans of fibroblasts derived from human embryonic lungs were first reported by Hayflick (1). Then, the correlation between doubling potentials of cells and maximal life spans of donor animals (2) as well as the inverted correlation between doubling potentials of human fibroblasts and ages of donors were established (3). Thus, it has been thought that cells age as donors age, or cells in vitro at least mimic parts of various processes of in vivo aging, although the mechanisms of cellular aging are not yet known.
KeywordsCellular Aging Population Doubling Ataxia Telangiectasia Xeroderma Pigmentosum Ataxia Telangiectasia
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