Environment and Aging: An Approach to the Analysis of Aging Mechanisms Using Poikilothermic Vertebrates
Epidemiological data and various circumstantial evidence suggest that the rate of aging in humans is influenced by many environmental conditions, such as nutrition, climate, or more complicated factors, including social conditions. Research designed to analyze the relationship between each environmental factor and the aging of organisms has been carried out using laboratory animals, particularly mice and rats. However, it is difficult to draw either specific or general conclusions regarding these relationships, since, in mammals, homeostatic mechanisms are well developed, and cells within the individuals are not always directly exposed to environmental conditions. One possible approach toward solving this problem would be to reevaluate the use of simple animal models, together with that of using cultured cells of animals and Poikilothermic vertebrates. These animals reflect environmental conditions more directly than mammals do (Fig. 1). Data or comments on environmental effects, such as temperature, nutrition, photoperiod, radiation and chemical trace elements on the life span of small laboratory fish will be presented.
KeywordsLife Span Aging Mechanism Aging Phenomenon Pineal Body Chemical Trace Element
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