Environment and Aging: An Approach to the Analysis of Aging Mechanisms Using Poikilothermic Vertebrates

  • Nobuo Egami
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


Epidemiological data and various circumstantial evidence suggest that the rate of aging in humans is influenced by many environmental conditions, such as nutrition, climate, or more complicated factors, including social conditions. Research designed to analyze the relationship between each environmental factor and the aging of organisms has been carried out using laboratory animals, particularly mice and rats. However, it is difficult to draw either specific or general conclusions regarding these relationships, since, in mammals, homeostatic mechanisms are well developed, and cells within the individuals are not always directly exposed to environmental conditions. One possible approach toward solving this problem would be to reevaluate the use of simple animal models, together with that of using cultured cells of animals and Poikilothermic vertebrates. These animals reflect environmental conditions more directly than mammals do (Fig. 1). Data or comments on environmental effects, such as temperature, nutrition, photoperiod, radiation and chemical trace elements on the life span of small laboratory fish will be presented.


Life Span Aging Mechanism Aging Phenomenon Pineal Body Chemical Trace Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. K. Liu and R. L. Walford, Observations on the life spans of several species of annual fishes and of the world’s smallest fishes, Exp. Gerontol. 5:241 (1970).PubMedCrossRefGoogle Scholar
  2. 2.
    R. K. Liu and R. L. Walford, The effect of lowered body temperature on life span and immune and non-immune processes, Gerontologia 18:363 (1972).PubMedCrossRefGoogle Scholar
  3. 3.
    Y. Hyodo, Effect of X-irradiation on the intestinal epithelium of the goldfish Carassius auratus II. Influence of temperature on the development of histological changes in the intestine, Rad. Res. 24:133 (1965).CrossRefGoogle Scholar
  4. 4.
    Y. Hyodo-Taguchi and N. Egami, Development of intestinal radiation injury and recovery at different temperatures in fish, in:“Comparative Cellular and Species Radiosensitivity,” T. Suguhara and Y. P. Bond, eds., Igakushoin, Tokyo (1969).Google Scholar
  5. 5.
    N. Egami, Long-term observations of mortality of irradiated fish at different temperatures, Rad. Res. 59:132 (1974).Google Scholar
  6. 6.
    Y. Kyono and N. Egami, The effect of temperature during the diethylnitrosamine treatment on liver tumorigenesis in the fish, Oryzias latipes, Eur. J. Cancer 13:1191 (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    Y. Kyono, Temperature effects during and after the diethylnitrosamine treatment on liver tumorigenesis in the fish, Qryzias latipes, Eur. J. Cancer, 14:1089 (1978).PubMedCrossRefGoogle Scholar
  8. 8.
    Y. Kyono, A. Shima, and N. Egami, Changes in the labeling index and DNA content of liver cells during liver tumorigenesis in the fish, Qryzias latipes, J. Natl. Cancer Inst., 63:71 (1979).PubMedGoogle Scholar
  9. 9.
    A. Comfort, Effect of delayed and resumed growth on the longevity of a fish (Lebistes reticulatus, Peters) in captivity, Gerontolgia 8:150 (1963).CrossRefGoogle Scholar
  10. 10.
    H. Urasaki, The role of pineal and eyes in the photoperiodic effects on the gonad of the Medaka, Qryzias latipes, Chronobiologica 3:228 (1976).Google Scholar
  11. 11.
    N. Egami, Radiation effects on life span of the fish, Qryzias latipes, in:“Proc. XI Int. Congress Gerontology,” 314 (1978).Google Scholar
  12. 12.
    N. Egami and H. Etoh, Effect of X-irradiation during embryonic stage on life span in the fish, Qryzias latipes, Expt. Gerontol. 8:219 (1973).CrossRefGoogle Scholar
  13. 13.
    N. Egami, M. M. H. Ghoneum, A. Kikuta, and K. Ijiri, Effects of radiation on life span and lymphoid tissues in the fish, Qryzias latipes, in:“Abst. 2nd Radiation Biology Center Int. Symp.,” 20.Google Scholar
  14. 14.
    G. B. Price, S. P. Modak, and T. Makinodan, Age-associated changes in the DNA of mouse tissue, Science 171:917 (1971).PubMedCrossRefGoogle Scholar
  15. 15.
    M. Matsui, A. Shima, and N. Egami, Autoradiographic detection of the template-primer activities of DNA by exogenous DNA polymerase in fixed mouse tissues, J. Fac. Sci., Univ. Tokyo, IV, 13:399 (1976).Google Scholar
  16. 16.
    A. D. Woodhead, Ageing changes in the liver of two Poeciliid fishes, the guppy, Poecilia (Lebistes) reticulata and the Amazon molly, P. formosa, Expt. Gerontol. 13:37 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Nobuo Egami
    • 1
  1. 1.Zoological Institute, Faculty of ScienceUniversity of TokyoHongo, Tokyo 113Japan

Personalised recommendations