Neuroendocrine Function and Aging

  • Arthur V. Everitt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


The life program from conception through growth, development, physiological aging, and the onset of terminal diseases leading to death is determined by both genetic and environmental factors. The course of aging and duration of life are affected by environmental factors such as temperature (1), food supply (2), and stress (3). These factors affect body functions by mediations of the neuroendocrine and autonomic nervous systems. For example, a rat or mouse living in a cold environment secretes more thyroxine (4) and catecholamines (5), which increase heat production and enable the animal to survive under these conditions (6). Survival in a hostile or rapidly changing environment is dependent upon adequate functioning of both the autonomic nervous and endocrine systems. The secretions of these two systems, neurotransmitters and hormones, regulate the vast majority of physiological activities throughout the body. Obviously, a deficiency of a specific neurotransmitter or hormone will have far-reaching effects on body function. This forms the basis of the neuroendocrine regulatory failure hypothesis of aging.


Luteinizing Hormone Estrous Cycle Preoptic Area Luteinizing Hormone Secretion Serum Luteinizing Hormone 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Arthur V. Everitt
    • 1
  1. 1.Department of PhysiologyUniversity of SydneySydneyAustralia

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