Translational Activity and Fidelity of Purified Ribosomes from Aging Mouse Livers

  • Nozumi Mori
  • Den’ichi Mizuno
  • Sataro Goto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


Since early years of modern molecular biology, it has been suggested that there must be some functional changes in the flow of genetic information which are almost universal to any type of cells, and hence very likely to be a general cause of functional deterioration during the aging of animals (1,2). In fact, various aspects of transcription and translation have been studied in relation to both the aging of tissues in vivo and cells in culture (3, 4).


Mouse Liver Translational Activity Aminoacyl tRNA Synthetase Altered Enzyme Modern Molecular Biology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Z. A. Medvedev, Ageing at the molecular level, in:“Biolgical Aspects of Ageing,” N. W. Shock, ed., Columbia University Press, New York (1962).Google Scholar
  2. 2.
    L. E. Orgel, The maintencance of the accuracy of protein synthesis and its relevance to ageing, Proc. Nat. Acad. Sci. U.S.A. 49:517 (1963).CrossRefGoogle Scholar
  3. 3.
    R. G. Cutler, in:“Interdisciplinary Topics in Gerontology,” H. P. von Hahn, ed., Vol. 9 and 10, S. Karger, Basel (1976).Google Scholar
  4. 4.
    F. M. Sinex, The molecular genetics of aging, in:“Handbook of the Biology of Aging,” C. E. Finch and L. Hayflick, eds., Van Nostrand Reinhold Co., New York (1977).Google Scholar
  5. 5.
    D. Gershon, Current status of age altered enzymes: Alternative mechanisms, Mech. Ageing Dev. 9:189 (1979).PubMedCrossRefGoogle Scholar
  6. 6.
    M. Rothstein, The formation of altered enzymes in aging animals, Mech. Ageing Dev. 9:197 (1979).PubMedCrossRefGoogle Scholar
  7. 7.
    J. Pitha, E. Stork, and E. Wimmer, Protein synthesis during aging of human cells in culture, Exp, Cell Res. 94:310 (1975).CrossRefGoogle Scholar
  8. 8.
    N. Mori, D. Mizuno, and S. Goto, Increase in the ratio of 18S RNA to 28S RNA in the cytoplasm of mouse tissues during ageing, Mech. Ageing Dev. 8:285 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    N. Mori, D. Mizuno, and S. Goto, Conservation of ribosomal fidelity during ageing, Mech. Ageing Dev. 10:379 (1979).PubMedCrossRefGoogle Scholar
  10. 10.
    W. I. P. Mainwaring, The effect of age on protein synthesis in mouse liver, Biochem. J. 113:869 (1969).PubMedGoogle Scholar
  11. 11.
    G. W. Britton and F. G. Sherman, Altered regulation of protein synthesis during aging as determined by in vitro ribosomal assays, Exp. Gerontol. 10:67 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    D. K. Layman, G. A. Ricca, and A. Richardson, The effect of age on protein synthesis and ribosome aggregation to messenger RNA in rat liver, Arch. Biochem. Biophys. 173:246 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    J. M. Gilbert and W. F. Anderson, Cell-free hemoglobin synthesis. II. Characterization of the transfer ribonucleic acid-dependent assay system. J. Biol. Chem. 245:2342 (1970).PubMedGoogle Scholar
  14. 14.
    M. R. Capecchi, Polarity in vitro, J. Mol. Biol. 30:213 (1967).PubMedCrossRefGoogle Scholar
  15. 15.
    D. I. Kurtz, The effect of ageing on in vitro fidelity of translation in mouse liver, Biochim Biophys. Acta 407:479 (1975).PubMedGoogle Scholar
  16. 16.
    D. Mariotti and R. Ruscitto, Age-related changes of accuracy and efficiency of protein synthesis machinery in rat, Biochim. Biophys. Acta 475:96 (1977).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Nozumi Mori
    • 1
  • Den’ichi Mizuno
    • 1
  • Sataro Goto
    • 1
  1. 1.Faculty of Pharmaceutical SciencesUniversity of TokyoBunko-ku, TokyoJapan

Personalised recommendations