Translational Activity and Fidelity of Purified Ribosomes from Aging Mouse Livers
Since early years of modern molecular biology, it has been suggested that there must be some functional changes in the flow of genetic information which are almost universal to any type of cells, and hence very likely to be a general cause of functional deterioration during the aging of animals (1,2). In fact, various aspects of transcription and translation have been studied in relation to both the aging of tissues in vivo and cells in culture (3, 4).
KeywordsMouse Liver Translational Activity Aminoacyl tRNA Synthetase Altered Enzyme Modern Molecular Biology
Unable to display preview. Download preview PDF.
- 1.Z. A. Medvedev, Ageing at the molecular level, in:“Biolgical Aspects of Ageing,” N. W. Shock, ed., Columbia University Press, New York (1962).Google Scholar
- 3.R. G. Cutler, in:“Interdisciplinary Topics in Gerontology,” H. P. von Hahn, ed., Vol. 9 and 10, S. Karger, Basel (1976).Google Scholar
- 4.F. M. Sinex, The molecular genetics of aging, in:“Handbook of the Biology of Aging,” C. E. Finch and L. Hayflick, eds., Van Nostrand Reinhold Co., New York (1977).Google Scholar