Hypertension, Vasculature and Aging

  • Akira Ooshima
  • Yukio Yamori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 129)


Essential hypertension develops with age, and its complication, arteriosclerosis, seems to be an accelerated form of aging process in blood vessels. With advancing age, the blood vessels lose elasticity and become stiff. This may be due in part to an increase in vascular connective tissue components. Special attention will be given in this report to the cardiovascular connective tissue and especially to the fibrils of collagen, which is known to be the major protein of connective tissue. The experiments were undertaken to elucidate an interrelationship between hypertension and vascular collagen metabolism. This report is a summary of experiments conducted during the past several years.


Prolyl Hydroxylase Normotensive Control Collagen Biosynthesis Medial Smooth Muscle Cell Vascular Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Akira Ooshima
    • 1
  • Yukio Yamori
    • 1
  1. 1.Department of PathologyShimane Medical UniversityIzumo 693Japan

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