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Chemical Aspects of Enzyme Stabilization and Modification for Use in Therapy

  • V. P. Torchilin
  • A. V. Mazaev
  • E. V. Il’ina
  • V. S. Goldmacher
  • V. N. Smirnov
  • E. I. Chazov

Abstract

In recent years it has been suggested that enzyme preparations could play a greater role in practical medicine (1). Unfortunately, the everyday clinical use of enzymatic preparations has been hindered by a number of factors. One such limitation has been the short duration of enzyme activity under physiological conditions; this has increased greatly the quantity of preparation to be used in the course of treatment. Another limitation has been the antigenic properties of enzymes, which appear as foreign proteins to the organism and thus may set the maximum preparation concentration limit in the organism. Other limitations have included possible nonspecific toxicity, enzyme accessibility to the action of endogenous proteases, and the high price and shortage of particular enzymes suitable for practical use.

Keywords

Enzyme Stabilization Bifunctional Reagent High Molecular Weight Substrate Water Soluble Carbodiimide Enzyme Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • V. P. Torchilin
    • 1
  • A. V. Mazaev
    • 1
  • E. V. Il’ina
    • 1
  • V. S. Goldmacher
    • 1
  • V. N. Smirnov
    • 1
  • E. I. Chazov
    • 1
  1. 1.National Cardiology Research CenterMoscowUSSR

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