Problems of Efficiency and Optimization in Enzyme Engineering

  • A. Köstner
  • E. Siimer


In spite of rapid research developments in the field of enzyme immobilization and the application of immobilized enzymes, only a very limited number of real industrial applications have been reported. We consider this gap between prospects and practical application as being caused in part by inadequate attention to the optimization and scale up of laboratory processes. We have come to the conclusion that the theoretical basis for the strategy of optimization in enzyme technology must be elaborated by analyzing combined kinetic and economic approaches. Such approaches have been discussed by a few authors (1,2) and have been developed in our earlier papers (3,4). Here we propose a general kinetic and economic equation for the analysis of a process in enzyme engineering.


Immobilize Enzyme Continuous Stir Tank Reactor Kinetic Coefficient Substrate Conversion Molar Yield 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • A. Köstner
    • 1
  • E. Siimer
    • 1
  1. 1.Laboratory of Enzyme TechnologyTallinn Technical UniversityTallinnUSSR

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