Fusion of Cell Fragments as a Method in Cell Genetics

Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 31)


Prior to the early sixties mammalian genetics had been concerned almost exclusively with the mechanisms by which genetic information was transmitted through the germ cells. Although this is still a central area recent technical developments now make it possible to analyze the organization and function of genes in somatic cells. Somatic cell genetics is a new subfield of genetics which aims to define genetic mechanisms involved in differentiation, neoplasia, inborn errors of metabolism, cell-virus interactions and other hereditary phenomena in somatic cells. The methodology of this new field includes generation and selection of mutant cell lines, phenotypic analysis of cultured cells, cell hybridization and gene transfer methods to mention but a few of the methods currently used.


Intact Cell Parental Cell Sendai Virus Cell Fragment Nuclear Donor 


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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • T. Ege
    • 1
  1. 1.Department of Medical Cell GeneticsMedical Nobel Institute, Karolinska InstitutetStockholm 60Sweden

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