The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation
The induction of thymic lymphocytic neoplasms in mice by murine leukemia viruses (MuLV) involves a complex series of interactions between endogenous retroviral gene sequences and target cells in the thymus (Kaplan, 1967). This virus-cell interaction is characterized by an exquisite target cell specificity for transformation, as compared to infection. Thus, some highly purified retroviruses (e.g., Moloney) can be obtained which can infect both mouse fibroblasts and thymic (or T) cells, but which are capable of transforming only a limited subset of thymocytes (N. Rosenberg, personal communication; Buchhagen et al., 1976). Since isolates from leukemic cells infect fibroblasts without transformation, and isolates from fibroblasts can both infect and transform some T lymphocytes, it is apparent that some very special relationship must exist between the transforming virus and its target cell (reviewed by Weissman and Baird, 1977).
KeywordsLymphoma Cell Murine Leukemia Virus Mixed Leukocyte Reaction Thymic Lymphoma Normal Thymocyte
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