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Monoclonal Antibodies to Tumor Antigens

  • Karl Erik Hellström
  • Joseph P. Brown
  • Ingegerd Hellström
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 11)

Abstract

Many tumors are immunogenic. This is indicated by the ability of sensitized recipients to reject a challenge of syngenic tumor cells and by the detection of humoral and cellular immune responses in vitro. Tumor-specific antigens are responsible for these phenomena. They have been demonstrated most clearly in neoplasms induced in experimental animals by large doses of chemical carcinogens or by oncogenic viruses. Whether spontaneous tumors and tumors induced with small doses of chemical carcinogens express such antigens remains controversial. Many human neoplasms, however, appear to be immunogenic, which has led to a massive effort to identify the antigens responsible, with a view to cancer diagnosis and therapy (for a review, see Hellström and Brown, 1979).

Keywords

Spleen Cell Tumor Antigen Myeloma Cell Human Melanoma Embryonal Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Karl Erik Hellström
    • 1
    • 2
  • Joseph P. Brown
    • 1
  • Ingegerd Hellström
    • 1
    • 3
  1. 1.Division of Tumor ImmunologyFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of PathologyUniversity of WashingtonSeattleUSA
  3. 3.Department of Microbiology / ImmunologyUniversity of WashingtonSeattleUSA

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